ID H0YMQ8_HUMAN Unreviewed; 128 AA.
AC H0YMQ8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=protein-glutamine gamma-glutamyltransferase {ECO:0000256|ARBA:ARBA00024222};
DE EC=2.3.2.13 {ECO:0000256|ARBA:ARBA00024222};
DE Flags: Fragment;
GN Name=TGM1 {ECO:0000313|Ensembl:ENSP00000453701.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453701.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000453701.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000453701.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL096870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0YMQ8; -.
DR SMR; H0YMQ8; -.
DR MassIVE; H0YMQ8; -.
DR PeptideAtlas; H0YMQ8; -.
DR ProteomicsDB; 40328; -.
DR Antibodypedia; 4193; 335 antibodies from 33 providers.
DR Ensembl; ENST00000559669.1; ENSP00000453701.1; ENSG00000092295.12.
DR UCSC; uc059aeb.1; human.
DR HGNC; HGNC:11777; TGM1.
DR VEuPathDB; HostDB:ENSG00000092295; -.
DR GeneTree; ENSGT01050000244939; -.
DR HOGENOM; CLU_1964511_0_0_1; -.
DR OMA; WSGNYSD; -.
DR ChiTaRS; TGM1; human.
DR Proteomes; UP000005640; Chromosome 14.
DR Bgee; ENSG00000092295; Expressed in lower esophagus mucosa and 97 other cell types or tissues.
DR ExpressionAtlas; H0YMQ8; baseline and differential.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF49; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE K; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:H0YMQ8,
KW ECO:0007829|PeptideAtlas:H0YMQ8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 3..69
FT /note="Transglutaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00927"
FT DOMAIN 77..120
FT /note="Transglutaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00927"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000453701.1"
SQ SEQUENCE 128 AA; 14010 MW; 7584A2E2C1EBC300 CRC64;
YLSVTFYTGV SGTIFKETKK EVELAPGASD RVTMPVAYKE YRPHLVDQGA MLLNVSGHVK
ESGQVLAKQH TFRLRTPDLS LTLLGAAVVG QECEVQIVFK NPLPVTLTNV VFRLEGSGLQ
RPKILNVG
//
