ID H0YP67_TAEGU Unreviewed; 760 AA.
AC H0YP67;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Signal peptide peptidase like 2B {ECO:0000313|Ensembl:ENSTGUP00000000064.2};
GN Name=SPPL2B {ECO:0000313|Ensembl:ENSTGUP00000000064.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000000064.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000000064.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000000064.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004366}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004366}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00004366}.
CC -!- SIMILARITY: Belongs to the peptidase A22B family.
CC {ECO:0000256|ARBA:ARBA00006859}.
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DR AlphaFoldDB; H0YP67; -.
DR STRING; 59729.ENSTGUP00000032975; -.
DR Ensembl; ENSTGUT00000000064.2; ENSTGUP00000000064.2; ENSTGUG00000000063.2.
DR GeneTree; ENSGT00940000158753; -.
DR HOGENOM; CLU_023799_2_1_1; -.
DR TreeFam; TF319186; -.
DR Proteomes; UP000007754; Chromosome 28.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR CDD; cd02129; PA_hSPPL_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007369; Peptidase_A22B_SPP.
DR InterPro; IPR006639; Preselin/SPP.
DR PANTHER; PTHR12174; SIGNAL PEPTIDE PEPTIDASE; 1.
DR PANTHER; PTHR12174:SF39; SIGNAL PEPTIDE PEPTIDASE-LIKE 2B; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04258; Peptidase_A22B; 1.
DR SMART; SM00730; PSN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 345..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 257..322
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 84467 MW; 54EB909E1728FC6F CRC64;
MGKRREQEGR ADRHRLREKS SVLQPRAGLT FPPALELHPD GLVDVLGEVQ DTLLLLLLLI
LRQSTGSPVK TRHPRRHGPS SPPRDPAAAG RAVGARRAPP PGRHRSSPPS SPRRRRRRRS
PFHSAPPEVT SRPAGARWRL GALGRDVRGG LWVPGAEGSG PAQVGTKRRR RGRPGMAAQP
ARLRLWLLLH LLPQVYCEYG MVHVLSEKGS SKGKDYCILF NSQWAHLPHD LGKASLLQLQ
DQTASVLCSP SDVPHGGFNN QIPMVMRGNC TFYEKVRLAQ INGARGLLIV SRERLVPPGG
NRSQYEEIDI PVALLSYTDM LDIGKSFGSS VKGAMYAPNE PVLDYNMVII FVMAVGTVAI
GGYWAGSRDV KKRYMKHKRD DGAEKHDDET VDVTPIMICV FVVMCCSMLV LLYFFYDHLV
YVIIGIFCLA ASIGLYSCLS PFVRRFPLGK CRIPDNNLPY FHKRPQIRML LLAVFCISVS
VVWGIFRNED QWAWVLQDAL GIAFCLYMLK TIRLPTFKGC TLLLLVLFVY DIFFVFITPF
LTKTGESIMV EVAAGPSDSA THEKLPMVLK VPRLNSSPLA LCDRPFSLLG FGDILVPGLL
VAYCHRFDIQ VQSSRVYFVA CTIAYGIGLL VTFVALALMQ MGQPALLYLV PCTLLTSFVV
ALWRRELAMF WTGSGFAKDL PQLPKDSSVP DSQQDAEQMT NPTLHLEELH ASASAEEELA
DTSTKTDQSE ISMAHSEEPT AQNKDDLESK CLNAEQNQLE
//
