ID H0YPJ6_TAEGU Unreviewed; 454 AA.
AC H0YPJ6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Growth/differentiation factor 9 {ECO:0000256|ARBA:ARBA00017637};
GN Name=GDF9 {ECO:0000313|Ensembl:ENSTGUP00000000195.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000000195.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000000195.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000000195.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer or heterodimer (Potential). But, in contrast to
CC other members of this family, cannot be disulfide-linked.
CC {ECO:0000256|ARBA:ARBA00026064}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; H0YPJ6; -.
DR STRING; 59729.ENSTGUP00000000195; -.
DR Ensembl; ENSTGUT00000000198.2; ENSTGUP00000000195.2; ENSTGUG00000000194.2.
DR GeneTree; ENSGT00940000159784; -.
DR HOGENOM; CLU_055377_1_0_1; -.
DR InParanoid; H0YPJ6; -.
DR OMA; TWRICVC; -.
DR OrthoDB; 5301288at2759; -.
DR TreeFam; TF351788; -.
DR Proteomes; UP000007754; Chromosome 13.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2000870; P:regulation of progesterone secretion; IEA:Ensembl.
DR CDD; cd19403; TGF_beta_GDF9; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR015617; Growth_differentiation_fac-9_C.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF19; GROWTH_DIFFERENTIATION FACTOR 9; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..454
FT /note="Growth/differentiation factor 9"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030172178"
FT DOMAIN 321..454
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 286..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 51217 MW; B7F9147694C77589 CRC64;
MESTWRICVC LSCCLPWLSA GTQFSPRSRG WEDSAEAPGF LAAPEDAANQ LSAGLQLPQG
EAPAHALLPP LLKVLHNRGP RGWHSEAPRL QPDSRALRYM KRLYRMSATR DGIPKAQRGR
LYNTVRLFTP CWECEHRPAH LGKGDVHSVD FLFNLDRVTA LEHLLKSVLL YSFDTSVPIS
SSITCMCHLS LKEHDFSSQV CPSISHSLAF SLHFDVRKRK WVEMDVTSFL QPLIAMNRRN
VHMALNFTCL MGDPQGSTKL ENAVNVTLVP PSLLLYLNDT SEQAYHRGSS LRHGRKSSSP
LVDPPKGDRG QGNPQGKRAS RQRRNENPKA APATSARNLS EYLKQFVFPQ NECELHSFRL
SFSQLRWDRW IIAPHRYSPQ FCRGECPRAL GHRYGSPVHT MVQTLIYERL DPSVPRPSCV
PAAYSPLSVL TIEPDGSIVY KEYEDMIATK CTCR
//
