ID H0YR77_TAEGU Unreviewed; 461 AA.
AC H0YR77;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Serine and arginine rich splicing factor 4 {ECO:0000313|Ensembl:ENSTGUP00000000785.2};
GN Name=SRSF4 {ECO:0000313|Ensembl:ENSTGUP00000000785.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000000785.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000000785.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000000785.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H0YR77; -.
DR STRING; 59729.ENSTGUP00000000785; -.
DR Ensembl; ENSTGUT00000000796.2; ENSTGUP00000000785.2; ENSTGUG00000000765.2.
DR GeneTree; ENSGT00940000156213; -.
DR HOGENOM; CLU_012062_34_2_1; -.
DR InParanoid; H0YR77; -.
DR OMA; EAYSDHE; -.
DR TreeFam; TF351335; -.
DR Proteomes; UP000007754; Chromosome 23.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
DR CDD; cd12337; RRM1_SRSF4_like; 1.
DR CDD; cd12600; RRM2_SRSF4_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR047190; RRM2_SRSF4-like.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR23003; RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23003:SF45; SERINE_ARGININE-RICH SPLICING FACTOR 4; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 2..72
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 104..177
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 72..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..240
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..393
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..443
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 53399 MW; D2CB6E71BAED0EEE CRC64;
MPRVYIGRLS YQARERDVER FFKGYGKILE VDLKNGYGFV EFDDLRDADD AVYELNGKDL
CGERVIVEHA RGPRRDSSYG SGRSGYGYRR SGRDKYGPPT RTEYRLIVEN LSSRCSWQDL
KDYMRQAGEV TYADAHKGRK NEGVIEFKSY SDMKRALEKL DGTEVNGRKI RLMEDRPGSR
RRRSYSRSRS HSRSRSRSRH SHKSRSRSAS SSRSKSRSRS RSVSRSRSKS RSRSKSHSRG
QKEKSRTPSK EDKSRSRSRS AEKSRNKSKD KSEGILHNND EKAKSRSHSK EKSRSRSGSK
ERGEARESVR SRSKEKSRSK DREKSISKGR SRSKSRDESR SRSHSKDKRK SRKRSRDDSR
SRSRSHSKSE KSKRRSKRDS KGSIKKRRKD SHERSRSGSK EKEQLKSESV KKEVKGKGED
AVSRSRSRSK SVSKPRSRSK SRSRSASQSH SQSRSRSRSR S
//
