ID H0YV24_TAEGU Unreviewed; 1017 AA.
AC H0YV24;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Pleckstrin homology and RUN domain containing M2 {ECO:0000313|Ensembl:ENSTGUP00000002145.2};
GN Name=PLEKHM2 {ECO:0000313|Ensembl:ENSTGUP00000002145.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000002145.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000002145.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000002145.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H0YV24; -.
DR Ensembl; ENSTGUT00000002165.2; ENSTGUP00000002145.2; ENSTGUG00000002075.2.
DR GeneTree; ENSGT00390000015175; -.
DR HOGENOM; CLU_012258_0_0_1; -.
DR InParanoid; H0YV24; -.
DR OMA; PSEMIHS; -.
DR Proteomes; UP000007754; Chromosome 21.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0032418; P:lysosome localization; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR CDD; cd13309; PH_SKIP; 1.
DR CDD; cd17680; RUN_PLEKHM2; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047327; RUN_PLEKHM2.
DR PANTHER; PTHR46556; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2; 1.
DR PANTHER; PTHR46556:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 36..158
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 769..871
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 230..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 112459 MW; 61116478199AF148 CRC64;
MEPAEVKDRI LENISLSVKK LQSYFAACED ETPAIRNHDK VLQRLCEHLD HALLYGLQDL
SSGYWVLVVH FTRREAIKQI EVLQHVATNL GRSRAWLYLA LNENSLESYL RLFQENLSLL
HKYYVKNALV CSHDHLTLFL TLVSGLEFIR FDLDLDAPYL DLAPYMPDYY KPQHLLDFEE
RLPSSVHGSD SLSLNSFNSV TSTNLEWDDS AIAPSSEDYD FGDVFPAMQT MPSRDWEDGD
LTDTLSCPRS AASEANGGRA AARSPTQRHN PFNEDRAEVP SSADTTPVHT ASRDKAEATP
EGTDQSESCT ELEVIRLAKK KKTGKKKKVK PEEAVNNPAP AAPEASGDSG INGLSDREEP
PRDREEPPRD REGDREELPR AGGPAAPGGP EEGGERAALG PLALRIPEMK DTSMESVGQP
LSKVMDRLNG QLDPGGWNAA LEPPGQPFRT GTPGETPDGL SSGDFSEGIS APMDFYRFTV
ESPNAAAPGG GHHDPPGPGQ PPHVSSSPEA PEEEESKEGE AVGAVEESER ASDEPQPSQT
ETTNPQALCE PKKEQPSPSL SSAEDSGVEE GQGSPSELTH PSEFRVDNNH LLLLMIHVFR
ENEEQLFRMI RMSTGHMEGN LQLIYVLLTD CYVYLIRKGA AEKPYMVEEA VSYNELDYIS
VGLDQQTVTL VCTNRRKQFL LDTADVALTE FFLVSLKSAM IKGCREPPYP SILTDATMEK
LALAKFVAQE SKCEACNVVV RFYGLVHWED PMDEALGPAS SSCSSAEPAV TKDGVLHYKA
GTSYLGKEQW KPCFVVLSNG ILYQYPDRTD VTPLLSINMG GEQCGGCRRS NTTDRPHSFQ
VILTDRPSLE LSAENEEDMA DWMQYFCQAV SKGVIPQGVA PTPCVPCCLV LTDEKVFTCH
EDCQTSFFRS LGTAELTDVT AVSTEAGKEY CILEFAQDSK EFLPPWVLYF SCTTELERFL
SALNVAWRNI YQVDLQHKAI LDAAVKKKCE DAQSLIDSAW QRSDSLCRGR AERDPWC
//
