GenomeNet

Database: UniProt
Entry: H0YWS7_TAEGU
LinkDB: H0YWS7_TAEGU
Original site: H0YWS7_TAEGU 
ID   H0YWS7_TAEGU            Unreviewed;       845 AA.
AC   H0YWS7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   07-JUN-2017, entry version 37.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSTGUP00000002751};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000002751, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000002751, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000002751}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTGUP00000002751}.
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DR   EMBL; ABQF01052762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01052763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01052764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59729.ENSTGUP00000002751; -.
DR   Ensembl; ENSTGUT00000002779; ENSTGUP00000002751; ENSTGUG00000002661.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H0YWS7; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Reactome; R-TGU-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-TGU-6798695; Neutrophil degranulation.
DR   Reactome; R-TGU-77387; Insulin receptor recycling.
DR   Reactome; R-TGU-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-TGU-983712; Ion channel transport.
DR   Proteomes; UP000007754; Chromosome 27.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0016241; P:regulation of macroautophagy; IEA:Ensembl.
DR   GO; GO:1901998; P:toxin transport; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    408    432       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    452    471       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    570       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    576    600       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    641    665       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    749    772       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    784    811       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   845 AA;  96846 MW;  3D98EDBD7B503DB2 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFHRK FVNEVRRCEE
     MDRKLRFVEK EIKKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR
     NFLELTELKF ILRKTQQFFD EAELHHQQMA DPDLLEESSS LLEPSEMGRG APLRLGFVAG
     VINRERIPTF ERMLWRVCRG NVFLRQAEIE NPLEDPVTGD YVHKSVFIIF FQGDQLKNRV
     KKICEGFRAS LYPCPETPQE RKEMASGVNT RIDDLQMVLN QTEDHRQRVL QAAAKNIRVW
     FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVADLDSI QFALRRGTEH SGSTVPSILN
     RMQTNQTPPT YNKTNKFTSG FQNIVDAYGI GTYREINPAP YTIITFPFLF AVMFGDFGHG
     ILMTLIAVWM VVRESRILSQ KSDNEMFNMV FSGRYIILLM GLFSTYTGLI YNDCFSKSLN
     MFGSSWSVRP MFNKANWSDA LLETTPLLQL DPAIPGVFGG PYPFGIDPIW NIASNKLAFL
     NSFKMKMSVI LGIFQMLFGV ALSLLNHIYF KKPLNIYLGF IPEMIFMSSL FGYLVILIFY
     KWTAYDAHTS KEAPSLLIHF INMFLFSYED TSNKMLYSGQ KGLQCFLVVV ALLCVPWMLV
     AKPLVLRQQY LRRKHLGTHN FGGIRVGNGP TEEDAEIIQH DQLSTHSEEG EEPTEDEVFD
     FGDTVVYQAI HTIEYCLGCI SNTASYLRLW ALSLAHAQLS EVLWTMVIHI GLSVRSLGGG
     LGLFFIFAAF ATLTVAILLV MEGLSAFLHA LRLHWIEFQN KFYTGTGFKF LPFSFDIIRE
     GRFDD
//
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