ID H0Z0E3_TAEGU Unreviewed; 522 AA.
AC H0Z0E3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Neutrophil cytosolic factor 2 {ECO:0000313|Ensembl:ENSTGUP00000004030.2};
GN Name=NCF2 {ECO:0000313|Ensembl:ENSTGUP00000004030.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000004030.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000004030.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000004030.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NCF2/NOXA1 family.
CC {ECO:0000256|ARBA:ARBA00008051}.
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DR AlphaFoldDB; H0Z0E3; -.
DR STRING; 59729.ENSTGUP00000004030; -.
DR Ensembl; ENSTGUT00000004074.2; ENSTGUP00000004030.2; ENSTGUG00000003893.2.
DR GeneTree; ENSGT00530000063843; -.
DR HOGENOM; CLU_041290_0_0_1; -.
DR InParanoid; H0Z0E3; -.
DR OMA; YATMEDW; -.
DR OrthoDB; 11738at2759; -.
DR TreeFam; TF329087; -.
DR Proteomes; UP000007754; Chromosome 8.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043020; C:NADPH oxidase complex; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0016175; F:superoxide-generating NAD(P)H oxidase activity; IEA:Ensembl.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IEA:Ensembl.
DR GO; GO:0006909; P:phagocytosis; IEA:InterPro.
DR GO; GO:0045730; P:respiratory burst; IEA:InterPro.
DR GO; GO:0042554; P:superoxide anion generation; IEA:Ensembl.
DR CDD; cd12046; SH3_p67phox_C; 1.
DR CDD; cd11871; SH3_p67phox_N; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR034889; NCF2_SH3.
DR InterPro; IPR035546; p67phox_SH3_1.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15175:SF3; NEUTROPHIL CYTOSOL FACTOR 2; 1.
DR PANTHER; PTHR15175; NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF13181; TPR_8; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 71..104
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 241..300
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 458..517
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 438..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 58848 MW; 70902F51E48FB1E9 CRC64;
MSLVETIRLW QEGVCAADRK EWSAALEAFA AVQNPPAKIC FNIGCIQLVL GKLAEAEQAF
TRSIGCDKHL AVAYFQRGTV FYRRQNHGKA IEDFKEALAQ LRGNQLIDYK ILGLRYRLFA
CEQILYNIAL VYATTGNWEK AEEHLTLAMS MKSEPQHNKI DRAMEAILKQ KLCELVAIPV
GKLFRPNEKQ VAQLEKKDYL GKAMVVASVV DKDDFSGFAP LQPQASGPPP RPKTPEILRA
LRGQPHRVMY EFIPETAEEL QVLPGNIVFV LKKEKDNWAT VMFNGKKGIV PCNFLEPVEL
QNKLYIQEET PVEAEIPESP TSPVPEKPRR LAPDYVPATM VQPRDTAKEA EPTLSRPHVL
KVHYKFTVAL RVDRGLSYRE LLELVCKKLE LQPEHTELRY KPVEGQELLP LRAENVEVAW
SQSKDNCLTV WCNGTEGEGF VPDSKPGESP QEATPGEMGP NHVVAQYSYE ATQPEDLEFQ
AGDTILVLSK VNEDWFEGEC RGRTGIFPSA FVQQPNTEHP EK
//
