ID H0Z1T4_TAEGU Unreviewed; 587 AA.
AC H0Z1T4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Short chain dehydrogenase/reductase family 42E, member 1 {ECO:0000313|Ensembl:ENSTGUP00000004524.2};
GN Name=SDR42E1 {ECO:0000313|Ensembl:ENSTGUP00000004524.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000004524.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000004524.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000004524.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR AlphaFoldDB; H0Z1T4; -.
DR STRING; 59729.ENSTGUP00000004524; -.
DR Ensembl; ENSTGUT00000004572.2; ENSTGUP00000004524.2; ENSTGUG00000004400.2.
DR GeneTree; ENSGT00940000158070; -.
DR HOGENOM; CLU_007383_6_8_1; -.
DR InParanoid; H0Z1T4; -.
DR OMA; QRWIPQP; -.
DR TreeFam; TF313574; -.
DR Proteomes; UP000007754; Chromosome 11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 480..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..478
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
FT REGION 1..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 63634 MW; F87CFAE3C734B37C CRC64;
MGDQGWGTGV QGRGTGDQDR GTGDQGWGKG DQGRGTGGSG PRLVQLPATI TPELFSHSCP
DPDRCRGCGT NTGPGQALIS PPSPVPERPG LRGEGSSSRG PARKSPRARL AGAAQAQRPA
AISGRPRPSR LHCPAPLPGS LARLPCPAPA PLPGSLARPQ LHCPAPLPGS LARLGTAPAI
RQRRRSFPAH GAEGNKMEEG NAAKERVLIT GGGGYFGFRL GCAIYQKGVD VILFDVVKPL
QTVPEGIKFM QGNICCLSEV EEALRDVICV FHIASYGMSG REQLNRKLIE DVNVKGTENV
IQACKSRGVS SLVYTSTYNV IFGGQIIENG DESLPYLPLH LHPDHYSRTK SLAEMKVLEA
NGAELGNGRG VLRTCALRPA GIYGPGEQRH LPRIVSYIER GLFKFVYGDP LSLVEFVHVD
NLVQAHVLAS EALRASKQHI AAGQAYFISD GKPVNNFEFF RPLVEGLGYK FPTWRLPLSL
VYFFAFLTEI VHFLVGRVYN FQPLLTRTEV YKTGVTHYFS MAKARKELGY EPQQYSLDEV
VEWFRSQGCG PKARNYTMMQ LVRDGGLLVV LIAVLVSWLP SAATFSL
//