ID H0Z250_TAEGU Unreviewed; 2482 AA.
AC H0Z250;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Bromodomain PHD finger transcription factor {ECO:0000313|Ensembl:ENSTGUP00000004640.2};
GN Name=BPTF {ECO:0000313|Ensembl:ENSTGUP00000004640.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000004640.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000004640.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000004640.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 59729.ENSTGUP00000028437; -.
DR Ensembl; ENSTGUT00000004689.2; ENSTGUP00000004640.2; ENSTGUG00000004512.2.
DR GeneTree; ENSGT00940000154830; -.
DR HOGENOM; CLU_244754_0_0_1; -.
DR TreeFam; TF316840; -.
DR Proteomes; UP000007754; Chromosome 18.
DR GO; GO:0016589; C:NURF complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd15559; PHD1_BPTF; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 250..310
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 400..447
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1363..1382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1500..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1878..1908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2123..2166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2400..2465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 916..943
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1927..1954
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2367..2394
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 140..197
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1303..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1422..1443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1505..1520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1575..1591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2123..2149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2400..2417
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2418..2434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2435..2465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2482 AA; 274000 MW; C92131689048FD30 CRC64;
MRGRRGRPPK QQQPAAAAAP ASAPAPAGPI GGLRSRQRGS SRGRWAAAAQ AETAGPKQKG
AGAAQASSPA AAASPRGGGK RKAGGGGGST PGGGGSGGKG RGRAGAAGAG GGGGAGGSCN
SQGRAASSRR SISKVVYDDH ESEEEEEESM VSEEEEEEGD PEDNQDSEEE EEEEIMEEED
DDDSDYPEEM EDEDDASYCT ESSFRSHSTY SSTPGRRRQR AHRPRSPILE EKDIPPLEFP
KSSEDLMVPS EHIMNVIAIY EVLRNFGTVL RLSPFRFEDF CAALVSQEQC TLMAEMHIVL
LKAVLREEDT SNTTFGPADL KDSVNSTLYF IDGMTWPEVL RVYCESDKEY HHVLPYQETE
DYPYGPVENK IKVLQFLVDQ FLTTNIAREE LMSEGVIQYD DHCRVCHKLG DLLCCETCSA
VYHLECVKPP LEEVPEDEWQ CEVCVAHKVP GVTDCVAEIQ KNKPYIRHEP IGYDRHRRKY
WFLNRRIIIE EDSESEKDKK IWYYSTKIQL AELIECLDKD YWEADLCKTL DEMREEIHRH
MDVTEDLTNK ARGSNKSFLS AANDEILDII RARKGEIVED KNTGDEEAEK TKSDVDNDQT
DAERDKEESG DQDKIEETHS EQDVEKERTE ALGDKSNSVT SSTDDSTTNP SAGENSCSEG
KDAVGCQSET LDSNNVAEKK VASELPLELS GTEGEKSNGE RSDSPGAGKG APGSTRMLTR
LRNPDSKLSQ MKSQQVAAAS NEANKLYKET REVLVVNSQG EVSRVSTKKD VVIKGNMNNY
FKLGQEGKYR VYHNQYATNS FALNKHQHRE DHDKRRHLSH KFCLTPAGEF KWNGSVHGSK
VLTISTLRLT IIQLENNIPA SFLHPNWASH RSNWIKAVQM CSKPREFALA LAILECAIKP
VVMLPIWRES LGHTRLRRMT AIEREEKEKV KKKERKQEEE ETMQQATWVK YTFPVKHQVW
KQKGEEYRVT GYGGWSWISK THVHRFMPKL PGNTNANYRK LLSSNSLTQS YFFFTVEKDI
NGENDKVIKE EPMDVDDVKI ESSIKDEESH CKRDIINVSE GFHLRTCYKR KVKSSKLDGL
LERRIKQFTL EEKQRLEKIK LEAGAKTGGI RSVSPQKNTD ELQTRNGKGG SQFDSSSQDK
SYTSDKTQAE DAEQDCLPIS SISCTKTGDE DETSLPLSNR LSKEGQLLDE DSPQCSEGDS
SVQNDGRENN PEPSTADECQ GQEALGQSES SLVDGLKQTS AEGRIKWDVS ETNEKPLKQK
LPITRVSQRE LENLGPVVPE SSCRREAVGT LEKADSEGNS EQQSKDPENN CMIKSHMETT
SSQESEMEEE IAPVKTESKS EKLILQQKSA NKDLESFKTG LISERDLESQ TLEHMDGEDD
NEDLLSSKLT EANGQNKGQE LKVDTDAMNK YLDQTNVNTI TDKKNNKDEE TETEEEKSSF
QMNGKDNDIK ALSNDACLVK NTCEAKAGGD IEPKVNNINK SIPEHEIKPL TFKESSVKPF
MNGDIVGEDT KDKKNVDSKS HLQSSPESGE TLQSASVGCA SLPTQPVCKE NNLSSETESM
ETEAIEEKKD APSPVTSCEE SSLSSHFADQ NGVQTYKMEN INGESKMKTV ITEVTTTTST
VSTESKTVFK VAETGAASDE KTTVVSSTEN CAISTVTTTT TVTKLTTPAS ESNSDVISVQ
EHSKTVVTTT VTDSLTTPEG TLVTSMTVSK EYSTKDKVKL MKFTRPKKTR SGTALPSYRK
FVTKSSKKSI FVLPNDDLKK LARRGGIREV PYFNYNAKPA LDIWPYPSPR PTFGITWRYR
LQTVKSLAGV SLMLRLLWAC LKWDDMAAKA PPGGGTTRTE TTETEITTTE IIKRRDVGPY
GIRSEYCIRK IICPIGVPEA PKETPTPQRK GLRSSALRPK RPETPKQTGP VIMETWVAEE
ELELWEIRAF AERVEKEKAQ AVEQQAKVSE QKKAEDSTAT TVSTPQKVVV GPLTGPVPTG
TKVVLTTKVG SPATVTFQQN KNFHQTFATW VKQGQSSTGV VQVQQKVLGI IPSTTGASQT
FTSFQPRTAT VTIRPNTTGT LGTTSTSQVV QGTPLRPGMT VIRTPLQQST LGKAIIRTPV
VVQQGQTQQV VTQIIRGQPV STAVSSTSTA SSSTGQKTIT SSGTAPQQAQ PQTPAPPPRP
QQGQVKLTMA QLTQLTQGQG GSQGLTVVIQ GQGQTTGQLQ LIPQGVTVIP GPGQQLMQAA
MPNGTIQRFL FTPLPAAATT ASTTTTTVST STSVFIFYFG FCIILQVVMK QNAVVEHLKQ
KKMLTPAERE ENQRMIVCNQ VMKYILDKID KEEKQAAKKR KREESVEQKR SKQNATKLSA
LLFKHKEQLK AEILKKRALL DKDLQIEVQL KRDLTKIKKE KERAQAAAAA AAAAAAAAAA
AAPPPPPPVP PAPPQLPAAS VTSSSSTTVP VPVSSQKRKR EEEKDSSASK SKKKKMISTT
SKETKKDTKL YCICKTPYDE SK
//
