ID H0Z351_TAEGU Unreviewed; 1435 AA.
AC H0Z351;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Nuclear receptor binding SET domain protein 3 {ECO:0000313|Ensembl:ENSTGUP00000004993.2};
GN Name=NSD3 {ECO:0000313|Ensembl:ENSTGUP00000004993.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000004993.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000004993.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000004993.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_002197925.1; XM_002197889.2.
DR RefSeq; XP_012425973.1; XM_012570519.1.
DR STRING; 59729.ENSTGUP00000004993; -.
DR Ensembl; ENSTGUT00000005043.2; ENSTGUP00000004993.2; ENSTGUG00000004829.2.
DR GeneID; 100224170; -.
DR KEGG; tgu:100224170; -.
DR CTD; 54904; -.
DR GeneTree; ENSGT00940000155355; -.
DR HOGENOM; CLU_004494_2_1_1; -.
DR InParanoid; H0Z351; -.
DR OMA; DAGWPTY; -.
DR OrthoDB; 950362at2759; -.
DR TreeFam; TF329088; -.
DR Proteomes; UP000007754; Chromosome 22.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140952; F:histone H3K27 dimethyltransferase activity; IEA:Ensembl.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:Ensembl.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0140946; F:histone H3K4 dimethyltransferase activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0140537; F:transcription regulator activator activity; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR CDD; cd15649; PHD1_NSD3; 1.
DR CDD; cd15652; PHD2_NSD3; 1.
DR CDD; cd15655; PHD3_NSD3; 1.
DR CDD; cd15658; PHD4_NSD3; 1.
DR CDD; cd15661; PHD5_NSD3; 1.
DR CDD; cd20163; PWWP_NSD3_rpt1; 1.
DR CDD; cd20166; PWWP_NSD3_rpt2; 1.
DR CDD; cd19212; SET_NSD3; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR041306; C5HCH.
DR InterPro; IPR047456; PHD2_NSD3.
DR InterPro; IPR047458; PHD4_NSD3.
DR InterPro; IPR047527; PHD5_NSD3.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR047451; PWWP_NSD3_rpt1.
DR InterPro; IPR047453; PWWP_NSD3_rpt2.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047461; SET_NSD3.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22884:SF473; HISTONE-LYSINE N-METHYLTRANSFERASE NSD3; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF17982; C5HCH; 1.
DR Pfam; PF00855; PWWP; 2.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00249; PHD; 5.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00293; PWWP; 2.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50812; PWWP; 2.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 269..332
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 698..745
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 958..1020
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 1091..1141
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1143..1260
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1267..1283
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 107..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1032..1059
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1293..1320
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 107..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..143
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1435 AA; 160615 MW; 79AF238C768137FE CRC64;
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EEAFDGSSDI AEDGGRTPYE AALQPGFQYP
TAEELPPLSN GYPPAISMYE PQAKYQTYAQ YPNGSANGFG TVRNFSPPEY YQLENSSNRP
HEVLEKSSPP QPPPLPPPSA PQVVIPKKTG SPEIKLKITK TIQNGRELFE SSLCGDLLNE
VQAREYAKAK HEGRKEKRKK SSKHDSSRSE ERKSHKIPKL EPEEQNRPNE RLSTLSERPR
EDAVLEEAPV QQLVPSLPTQ VPHDVKFQVG DLVWSKVGTY PWWPCMVSCD PQLDVHTKIN
TRGAREYHVQ FFSNQPERAW VHEKRVREYQ GHKQYEQLLA EAAKQASNHS EKQKIRKPRP
QRERAQWDIG IAHAEKALKM TREERIEQYT FIYVDQEPEE ALAKAKKTAA SKSEAKKNRR
PKAAPSSQPE HASAVAAGSS PCHGEARRQG QRRQSSLEEE EAPPVKIAWK TAAARKSLPA
SITMHNLDLQ KCNMSPVVKI EQVFALQNAA GDGKLIDQFV YSTKGVGNKT EISIKGQEKL
NSSSAQRSEK AVVQNASSPE TTSGAAGCVE KKQQRRSIRT RSESEKSTEV VPKKKIKKEQ
VEAVPLAAVK TGLQKGASEI SDSCKPLKKR SRASTDMELT SSAYRDTSDS DSRGLNDLQG
SFGKRSDSPS ATADADASDV QSVDSSLSRR GTGTSKKDTV CQICESSGES LLACEGECCS
MFHLECLGLK AMPEEKFICT ECKNGEHTCF SCKLPGKDVK RCSVSTCGKF YHEACVRKFA
TALFESRGFR CPQHCCTACS MDKDMHKASK GRMARCLRCP VAYHSGDGCI AAGSLFVSSH
ILICSNHSKR THSSSAVNVG FCFVCARGLV VQDHSDPLFS SYAYKSHYLL NESNRAELMK
LPMIPPPSSA SKKKCEKGGK LLCCESCPAS FHPECLSIEM PEGCWNCNDC KAGKKLRYKQ
IVWVKLGNYR WWPAEICNPR SVPLNIQGLK HDIGDFPVFF FGSHDYYWVH QGRVFPYVEG
DKSFAEGQTS INKTFKKALE EAAKRFQELK AQRESKEALE IERNSRKPPP YKHIKSNKVI
GKVQIQVADL SEIPRCNCKP SDENPCGLES ECLNRMLQYE CHPQVCPAGE RCQNQCFTKR
LYPDAEIIKT ERRGWGLRTK RSIKKGEFVN EYVGELIDEE ECRLRIKRAH ENSVTNFYML
TVTKDRIIDA GPKGNYSRFM NHSCNPNCET QKWTVNGDIR VGLFALCDIP AGMELTFNYN
LDCLGNGRTE CHCGAENCSG FLGVRPKTAF ATANEEKVKN AKLKQKKRKI KTEQKQMHED
NCFQCGDGGE LVMCDKKDCP KAYHLLCLNL TQPPFGKWEC PWHQCDICSN PAVSFCEFCP
HSFCKDHEKG ALVPSALDGR LCCSAHDPKS PVAPEYWSKI KCKLEAQNAV EEAKE
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