ID H0Z449_TAEGU Unreviewed; 323 AA.
AC H0Z449;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Hsp90 co-chaperone Cdc37-like 1 {ECO:0000256|ARBA:ARBA00040086};
GN Name=CDC37L1 {ECO:0000313|Ensembl:ENSTGUP00000005343.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000005343.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000005343.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000005343.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Co-chaperone that binds to numerous proteins and promotes
CC their interaction with Hsp70 and Hsp90.
CC {ECO:0000256|ARBA:ARBA00037145}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
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DR RefSeq; XP_002193160.2; XM_002193124.3.
DR AlphaFoldDB; H0Z449; -.
DR STRING; 59729.ENSTGUP00000005343; -.
DR Ensembl; ENSTGUT00000005396.2; ENSTGUP00000005343.2; ENSTGUG00000005189.2.
DR GeneID; 100219744; -.
DR KEGG; tgu:100219744; -.
DR CTD; 55664; -.
DR GeneTree; ENSGT00390000013443; -.
DR HOGENOM; CLU_046495_1_0_1; -.
DR InParanoid; H0Z449; -.
DR OMA; GKWTKDD; -.
DR OrthoDB; 297041at2759; -.
DR TreeFam; TF101059; -.
DR Proteomes; UP000007754; Chromosome Z.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF2; HSP90 CO-CHAPERONE CDC37-LIKE 1; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 123..278
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 37866 MW; 5A33C517B7010541 CRC64;
MALWLPHSRD GGAPQEEDQE RAQDAAFRQR LSEVQTYNQG IELACQKERE FVKHSVESTW
NLAEAQQKFG SLALHNSESC DQESAQARTE AAELRWREEE WRRKEEALNQ RERQNLWNTD
PVSKEVFNKS FINQKRKEIE DEAVSEPLMQ KHEQKIRHFG MLSRWDDSQR FLSDHPYLVC
EETSRYLMLW CFHLEAEQKR ALMEQVAHQA VVMQFIIEIA RSCNVDPRGC FRLFFQKAKT
GEGYFEAFKN ELEAFKTRVR VWSQSHGFQT MLLHDLSVSP GVGEWTSFLQ NTGDLQGSIN
TDVCSFNSVI QRDEEESKMM DTL
//
