ID H0Z8J1_TAEGU Unreviewed; 903 AA.
AC H0Z8J1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Dystrophin related protein 2 {ECO:0000313|Ensembl:ENSTGUP00000006894.2};
GN Name=DRP2 {ECO:0000313|Ensembl:ENSTGUP00000006894.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000006894.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000006894.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000006894.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H0Z8J1; -.
DR STRING; 59729.ENSTGUP00000032328; -.
DR Ensembl; ENSTGUT00000006963.2; ENSTGUP00000006894.2; ENSTGUG00000006639.2.
DR GeneTree; ENSGT00940000153467; -.
DR HOGENOM; CLU_001187_0_0_1; -.
DR TreeFam; TF337303; -.
DR Proteomes; UP000007754; Chromosome 4A.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16248; EFh_DRP-2; 1.
DR CDD; cd00176; SPEC; 1.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF16; DYSTROPHIN-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 1.
DR Pfam; PF00397; WW; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00150; SPEC; 2.
DR SMART; SM00456; WW; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 308..341
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 561..617
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 20..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 738..832
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 838..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..883
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 102432 MW; 998F5677C6B19A23 CRC64;
MQPLVMQEWL HVLPPCPEWH TPEQAQPSSP ACPLPQVEAS QDGAGPSCVT PRAPSGAARP
QAPLEMNLCW NEIKKKSHSL RARLEAFSDH SGKLQQEKET HTAFMEEVKS RGPYIYSVLE
SAQAFLSQHP FEELEEPTLE SKDVSPRHRI QNISRFVWKQ ANVASELWEK LTARCVDQHR
HIERTLEQLL EIKGAMEELS MTLDQAESVR ETWEPIGDLF IDSLPEHIQS TKLFKEELSP
VKDGVKVVND LAHQLAISDV HLCMENSRTL EQINTRWKQL QASINERLKQ LQDAHRDFGP
GSQHFLSSSV QVPWERAISP NKVPYYINHQ AQTTCWDHPK MTELYQTLAD LNNIKFSAYR
TAMKLRRVQK ALRLDMVTLA TALEIFNEHD LQPSDRAMDV VEVIHCLTAL YERLEEERGI
LVNVPLCVDM SLNWLLNVFD SGRSGKMRAL SFKTGIACLC GTEVKEKFQY LFSQVANAGG
LCDQRHLGVL LHEAIQVPRQ LGEVAAFGGS NVEPSIRSCF RFSNGKSAIE ASQFLEWANL
EPQSMVWLAV LHRVAMAEQV KHQTKCSVCR QCPIKGFRYR SLKQFNVDIC QTCFLTGRAS
KGNKLHYPIM EYYTPTTSSE NMRDFATTLK NKFRSKQYFS KHPQRGYLPV QSVLEADFSE
TPASSPMLPH ADTHSRIEHF ASRLAEMESQ NCSFFSDSLS PDDSLDEDQY LLRHSSPITD
REPGGSQQLP GGLNMDDKGE LERVLAHLED ENRILQGELR RLKWQHDEAV ESPSLATGSP
ESVQDPRNEE LLAEARILRQ HKSRLETRMQ ILEDHNKQLE SQLHRLRELL LQPPAESEGN
GSAASSLASS PHQSEGSQAK EKEHNTPDTE TADEVEAKTQ EVSMCLEDIM EKLRSAFPTS
RGT
//
