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Database: UniProt
Entry: H0ZAP3_TAEGU
LinkDB: H0ZAP3_TAEGU
Original site: H0ZAP3_TAEGU 
ID   H0ZAP3_TAEGU            Unreviewed;       806 AA.
AC   H0ZAP3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   07-JUN-2017, entry version 35.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TCIRG1 {ECO:0000313|Ensembl:ENSTGUP00000007648};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007648, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000007648, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000007648}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTGUP00000007648}.
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DR   EMBL; ABQF01001753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01001754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01001755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59729.ENSTGUP00000007648; -.
DR   Ensembl; ENSTGUT00000007727; ENSTGUP00000007648; ENSTGUG00000007403.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H0ZAP3; -.
DR   OMA; WRACRGF; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Reactome; R-TGU-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-TGU-6798695; Neutrophil degranulation.
DR   Reactome; R-TGU-77387; Insulin receptor recycling.
DR   Reactome; R-TGU-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-TGU-983712; Ion channel transport.
DR   Proteomes; UP000007754; Chromosome 5.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0016236; P:macroautophagy; IEA:Ensembl.
DR   GO; GO:0007039; P:protein catabolic process in the vacuole; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    542    561       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    573    593       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    635    657       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    766    792       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   806 AA;  91072 MW;  31123CCEA3D25ADA CRC64;
     MGSLFRSEEV CLAQLFLQSA SAYSCISELG ERGLLEFRDL NPKVSPFQRR FVGEVRRCEE
     MEKTFTFLQQ ELRAAGRLPA PCPESPRAPA AREALRVQEQ SEQLAQELRE VSRSRSSLRD
     RLRDLRQHLH AHPSAPHRHR PPWAPRRGHG LSEREPILDP SLHHHLDRKI NFVAGVIHPW
     RVTAFERLLW RACRGYLVAS FVEMPEPMED PATGESITWV IFLISYWGEQ IGQKIRKISN
     CFHCQVYGYP ESEASRTEAI TRLHGQIQEL SVTLEETEKY LAEVLDKVAQ VLPTWRVQVQ
     KMKAIYLVLN QCSFDVTKKC LIAEVWCPVR DLTQVQDALR QGSSGSSVEC FVQRVPTTES
     PPTLIRTNKF TAGFQSIVDA YGVASYQEVN PAPYAIITFP FIFAIMFGDV GHGLLMFLFA
     LWMVLYEDSP RLRQGTNEIW LTFFEGRYLI LLMGAFSIYT GFIYNECFSK ATAIFPSAWS
     VATMANHSSW SSAYLATHPS LTLDPNVTGV FQGPYPFGID PIWSLATNHL NFLNSFKMKM
     SVVLGIVHMG FGVMLGVFNH VHFQQRHRLV LEFLPEMIFL LALFGYLVFL IFYKWIKFSA
     ADSRVAPSIL IHFIDMFLFT SNAENLPLYP GQVPVQMVLV VLALASVPVL LLGTPLYQWC
     RQRAPRTVRL RAPLAAGEQE PLLEGQEAGN SVNATTEDVE SGGHSPDAKH DFAEIFMHQA
     IHTIEYCLGC VSNTASYLRL WALSLAHAQL SEVLWSMVMR NGFVGLSYVG GVVLVPVFAA
     FAVLTVAILL VMEGLSAFLH ALRLHW
//
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