ID H0ZDS4_TAEGU Unreviewed; 615 AA.
AC H0ZDS4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Netrin 4 {ECO:0000313|Ensembl:ENSTGUP00000008736.2};
GN Name=NTN4 {ECO:0000313|Ensembl:ENSTGUP00000008736.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000008736.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000008736.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000008736.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; H0ZDS4; -.
DR STRING; 59729.ENSTGUP00000008736; -.
DR Ensembl; ENSTGUT00000008829.2; ENSTGUP00000008736.2; ENSTGUG00000008466.2.
DR GeneTree; ENSGT00940000156615; -.
DR HOGENOM; CLU_016961_2_1_1; -.
DR InParanoid; H0ZDS4; -.
DR OMA; NNCQHNT; -.
DR TreeFam; TF352481; -.
DR Proteomes; UP000007754; Chromosome 1A.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0043237; F:laminin-1 binding; IEA:Ensembl.
DR GO; GO:0016322; P:neuron remodeling; IEA:Ensembl.
DR GO; GO:0060668; P:regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling; IEA:Ensembl.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03578; NTR_netrin-4_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR035811; Netrin-4_NTR.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF282; NETRIN-4; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 17..248
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 319..381
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 382..435
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 493..614
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 349..358
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 409..418
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 615 AA; 67440 MW; 44BC1DB78EA9C950 CRC64;
MDVFPGLGGA AAASSPCEKA CNPRMGNLAL GRALRTDTSC GRRGAERFCS YSEDAERRCR
RPSCGRCGGA QPGLAHPPAA MADSPFRLPR TWWQAARDAP RETIRLDLEA AFYFTHLIMV
FKSPRPAAMV LERSQDFGET WKPYKYFAAN CSATFGLEDD VRQRGAICTS RYSSPFPCTG
GEVIFRALSP PYAEEDPYSA EAQAQLKITN LRVRLLERQG CPCLPASPAP QPPPSLHYAI
YDFIVMGSCF CNGHADHCIP VAGFKPTKAA GVFHVVHGKC MCKHNTAGSH CQRCAPLYND
QPWQAADGKT GAPKECRSCK CNGHADTCHF DVDVWLASGN RSGGVCDNCQ HNTEGQHCQR
CKLGFYRDLR KPFSAPDACK PCSCHPVGSA VLPLGPGTFC DPSTGDCPCK PGVAGPRCDH
CLPGYWGFGP YGCRPCDCAR SCDPHTGDCH SSSSDVSWHN EAPPFQAVLN ESEPTWGWED
EQGFSALRHS GKCECKEQVL GNPKVFCGMK YTYVIKTKIL SAHDKGSHAE VSVKIKKVLK
STKLKILRGK RTLYPESWTN RGCTCPILNP GLEYLVAGHE DVRTGRLIVN MKSFVHQWKS
TLGRKVLEIL KRNCN
//
