ID H0ZEB0_TAEGU Unreviewed; 774 AA.
AC H0ZEB0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Short transient receptor potential channel 1 {ECO:0000256|ARBA:ARBA00013302};
GN Name=TRPC1 {ECO:0000313|Ensembl:ENSTGUP00000008922.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000008922.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000008922.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000008922.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Thought to form a receptor-activated non-selective calcium
CC permeant cation channel. Probably is operated by a phosphatidylinositol
CC second messenger system activated by receptor tyrosine kinases or G-
CC protein coupled receptors. Seems to be also activated by intracellular
CC calcium store depletion. {ECO:0000256|ARBA:ARBA00003698}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. TRPC1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009944}.
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DR AlphaFoldDB; H0ZEB0; -.
DR STRING; 59729.ENSTGUP00000008922; -.
DR Ensembl; ENSTGUT00000009019.2; ENSTGUP00000008922.2; ENSTGUG00000008641.2.
DR GeneTree; ENSGT01060000248594; -.
DR HOGENOM; CLU_005716_4_1_1; -.
DR InParanoid; H0ZEB0; -.
DR OMA; SRPTIVX; -.
DR TreeFam; TF313147; -.
DR Proteomes; UP000007754; Chromosome 9.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005457; TRPC1_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF56; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01642; TRPCHANNEL1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 181..243
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
SQ SEQUENCE 774 AA; 89095 MW; 606CB9FA9CB1A6EB CRC64;
MAALYQSADP SASASPNKLL ALKDVRQVKE ETTLDEKLFL LACDKGDYYM VKKLLEENSS
GEMNINCVDV LGRNAVTITI ENENLDILQL LLDYGCQSSD ALLVAIDSEV VGAVDILLNH
RPKRSSRPTI VKLMERIQNP EYSTTMDVAP VILAAHRNNY EILTMLLKQD ISLPKPHAVG
CECTLCTAKN KKDSLRHSRF RLDIYRCLAS PALIMLTEED PILRAFELSA DLKELSLVEV
EFRNDYEELA QQCKTFAKDL LAQARNSREL EVILNHTSSD EHVDKRGLLE ERMNLSRLKL
AIKYNQKEFV AQSNCQQFLN TVWFGQMAGY RRKHTCKKIL TVLMVGIFWP VLSLCYLLAP
KSRVGRIIHT PFMKFIIHGA SYFTFLLLLN LYSLVYNENK KNTMGPALER IDYLLIIWLI
GMVWSDVKRL WYDGLEDFLE ESRNQLSFVM NSLYLATFAL KVVAHNKFHD YAERKDWDAF
HPTLVAEGLF AFANVLSYLR LFFMYTTSSI LGPLQISMGQ MLQDFGKFLG MFLLVLFSFT
IGLTQLYDKG FTVNEEKDCA GIFCEQQSND TFHSFIGTCF ALFWYIFSLA HVAIFVTRFS
YGEELQSFVG AVIVGTYNVV VVIVLTKLLV AMLHKSFQLI ANHEDKEWKF ARAKLWLSYF
DDKCTLPPPF NVIPSPKTIC YLFNSLSKWI CSHTSSGKVK RQNSLKKRDE NYQKVMCCLV
HRYLTSMRQK MQSTDQATVE NLNELRQDLS KFRNEMRDLL GFRTSKYAMF YPRN
//
