ID H0ZF03_TAEGU Unreviewed; 577 AA.
AC H0ZF03;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=WSC domain containing 1 {ECO:0000313|Ensembl:ENSTGUP00000009165.1};
GN Name=WSCD1 {ECO:0000313|Ensembl:ENSTGUP00000009165.1};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000009165.1, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000009165.1, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000009165.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
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DR RefSeq; XP_002199844.1; XM_002199808.2.
DR RefSeq; XP_012424210.1; XM_012568756.1.
DR RefSeq; XP_012424211.1; XM_012568757.1.
DR AlphaFoldDB; H0ZF03; -.
DR STRING; 59729.ENSTGUP00000009165; -.
DR Ensembl; ENSTGUT00000009264.2; ENSTGUP00000009165.1; ENSTGUG00000008895.2.
DR GeneID; 100228077; -.
DR KEGG; tgu:100228077; -.
DR CTD; 23302; -.
DR GeneTree; ENSGT00940000158096; -.
DR HOGENOM; CLU_029239_1_0_1; -.
DR InParanoid; H0ZF03; -.
DR OMA; KDFEPFT; -.
DR OrthoDB; 3971278at2759; -.
DR TreeFam; TF324060; -.
DR Proteomes; UP000007754; Chromosome 19.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF5; WSC DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51212; WSC; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 142..234
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 245..342
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 577 AA; 66184 MW; F040FE90621E70E6 CRC64;
MAKAFFRLQK FLRRIQFLLF FLTAAYLMAG SLLLLQRTRL VLQQGSRGTP TNQALPVLEE
MSRVGIVDPR TLQNPRPGPR MLVGMDALQE PALDQRHSPH WLMARNSELR QLRRRWFHRF
TSNQEPLQTA GFKAVKHTVE HKGTYMGCFT QDSRERTLKG AVFYDLRKMT VAHCQEACAE
RAYSYAGLAY GAECYCGNTL PAAAARPEEC NSECKGQRGS VCGGVNRLSV YSMEPLWAGA
RPRRNVIYRG CFRAPENLTD TFPASLIQPN LTVEKCSEFC SKKEFPLAVI RGQECYCGYP
TRRFSLREGT DGRRCSGTHN VSSAAGGQYC LVYQTPVQDT RCTDRKFLTT KSKVFVALSS
FPGAGNTWAR HLIEHATGYY TGSYYFDGAL YNKGFKGEKD HWRSRRTICV KTHESGKTEI
EMFDSAILLI RNPYKSLMAE FNRKYAGHLG YATDHNWKSK EWPDFVNSYA SWWASHVLEW
LKYGKRLLVV HYEDLKQSLI PKLKEMVEFL NVTVTEDRLL CVENNRDGNF KRSGAKQKNF
EPFTQEMKDL INRYILTVDE ALRGRNFSGL PREYVPR
//
