GenomeNet

Database: UniProt
Entry: H0ZJZ3_TAEGU
LinkDB: H0ZJZ3_TAEGU
Original site: H0ZJZ3_TAEGU 
ID   H0ZJZ3_TAEGU            Unreviewed;      4912 AA.
AC   H0ZJZ3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 48.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSTGUP00000010913};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSTGUP00000010913};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000010913, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000010913, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000010913}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTGUP00000010913}.
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DR   EMBL; ABQF01014583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01014584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01014585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01014586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01014587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59729.ENSTGUP00000010913; -.
DR   Ensembl; ENSTGUT00000011027; ENSTGUP00000010913; ENSTGUG00000010491.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H0ZJZ3; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-TGU-2672351; Stimuli-sensing channels.
DR   Reactome; R-TGU-5578775; Ion homeostasis.
DR   Proteomes; UP000007754; Chromosome 3.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4223   4241       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4445   4465       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4519   4538       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4655   4676       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4713   4734       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4789   4812       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       54    109       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      116    161       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      169    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      230    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    352       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      555    753       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      969   1166       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1301   1506       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3966   4001       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4912 AA;  559425 MW;  94278AB7649B677E CRC64;
     NVPPDLSICT FVLEQSLSVR ALQEMLANTE EKAEGQDNTE SWQLSTKSAQ GGGHRTLLYG
     HAILLRHSYS GMYLCCLSTS RSSMDKLAFD VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR
     VGDDLILVSV SSERYLHLSY GNGSLHVDAA FQQTLWSVAP ISSGSEVAQG YLIGGDVLRL
     LHGHMDECLT VPSGEHGEEQ RRTVHYEGGA VSIHARSLWR LETLRVAWSG SHIRWGQPFR
     LRHITTGKYL SLLDDKSLLL TDKEKADVKS TAFCFRSSKE KLDIGTRKEV DGMGAPEIKY
     GDSICFIQHV DTGLWLTYQS ADAKSVRMGS LQRKAIMHHE GHMDDGLTLS RSQNEESRTA
     RVIRSTVFLF NRFIRGLDVL SKKVKSSTID LPIESVSLSL QDLIGYFHPP DEHLEHENKQ
     NRLRALKNRQ NLFQEEGMIN LVLECIDRLN VYSSAAHFAD VAGKEAGEAW KSILNSLYEL
     LAALIRGNRK NCAQFSGSLD WLISRLERLE ASSGILEVLH CVLVESPEAL NIIKEGHIKS
     IICLLDKHGR NHKVLDVLCS LCVCHGVAVR SNQHLICDNL LPGRDLLLQT RLVNHVSSMR
     PNIFLGISEG SAQYRKWYYE LMVDHLEPFV TAESTHLRVG WASTEGYSPY PGGGAEWGGN
     GVGDDLYSYG FDGLHLWSGC VARTVNSPNQ HLLRTDDVIS CCLDLSAPSI SFRINGQPVQ
     GMFENFNIDG LFFPVVSFSA GIKVRFLLGG RHGEFKFLPP PGYAPCFEAV LPKEKLKVEN
     SREYKQDRSY TRDLLGPTVS LSQAAFTPVP VDTSQIVLPP HLERIREKLA ENIHELWVMN
     KIELGWQYGP VRDDNKRQHP CLVEFSKLPE QERNYNLQMS LETLKTLLAL GCHVGIADER
     AEEKVKKMKL PKNYQLLSGY KPAPMDLSFI KLTPSQEAMV DKLAENAHNV WARDRIRQGW
     TYGIQQDVKN RRNPRLVPYA LLDDRTKKSN KDSLREAVRT LLGYGYNLEA PDQDHATRLD
     VCSGIMEKFR IFRTEKTYAV KAGKWYFEFE AVTAGDMRVG WTRPGCLPDQ ELGSDEEAFV
     FDGFKAQRWH QGNEHFGRSW LAGDVVGCMV DMNEHTMMFT LNGEILLDDS GSELAFKDFE
     VADGFLPVCS LGPSQVGRMN FGKDVSTLKY FTICGLQEGY EPFAVNTNRD ITIWWSKRLP
     QFLPVPQNHE HIEVMRIDGT IDSCPCLKVT QKSFGSQNSK TDVMFFRLSM PIECAEVFSR
     SAAGGLPGSG LFGPKNDLED YDADSDFEVL MKTAHGHLVP DRTEREKDAT KPELNNHKDY
     VQEKPSRLKQ RFMLRRTKPD YSMSHSARLT EDVLADDRDD YDYLMQTSTY YYSVRIFPGQ
     EPANVWVGWI TSDFHQYDTS FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESLSP
     GQGRNNNGLE IGCLVDAASG LLTFTANGKE LGTYYQVEPS TKLFPAVFAQ ATSPNVFQFE
     LGRIKNVMPL SAGLFKSEHK NPISQCPPRL HVQFLTHVLW SRVPNHFLKV DVSRISERQG
     WMIQCLNPLQ FMALHIPEEN RTIDILELTE QEELLKFHYH TLRLYSAVCA LGNNRVAHAL
     CSHVDESQLL YAIENKYMPG LLRAGYYDLL IDIHLNTYAT ARLMMNNEFI VPMTDETKSI
     TLFPDENKKH GLPGIGLSTS LRPRMQFSSP SFVSISSECF QFSPEFPLEI LKAKTIEMLT
     EAVQEGSLHV RDPVGGSTEF LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPRVFKEAMS
     QEDEIDFSEK EFSSDELKSE EGEEETRGEQ MPKEGLLQMK LPEPVKLQMC HLLQYLCDCQ
     VRHRIEAIVA FSDDFVAKLQ ENQRFRYNEV MQALNMSAAL TARKTKEFRS PPQEQINMLL
     NFKDDKNDCP CPEEIRDQLL DFHEDLMTHC GIELDEDGAL DGNSDSTIRG RLLYLMEKVT
     YLKKKQDEKT VDEDDKTSST LQQLISDTMV RWAQESVIED PELVRAMFVL LHRQYDGIGG
     LVRALPKTYT INSVSVEDTI NLLASLGQIR SLLSVRMGKE EEKLMIRGLG DIMNNKVFYQ
     HPNLMRALGM HETVMEVMVN VLGGGESKEI TFPKMVANCC RFLCYFCRIS RQNQKAMFDH
     LSYLLENSSV GLASPSMRGS TPLDVAAASV MDNNELALAL REPDLEKVVR YLAGCGLQSC
     PLLICKGYPD IGWNPVEGER YLDFLRFAVF CNGESVEENA NVVVRLLIRR PECFGPALRG
     EGGNGLLAAM EEAIQISEDR TRDGPSPSNG SSKTLEIEEQ EDDTIHMGNA IMTFYAALID
     LLGRCAPEMH LIHAGKGEAI RIRSILRSLI PLEDLVGVIS IAFHMPTIAK DGTVVEPDMS
     AGFCPDHKAA MVLFLDRVYG IEDQDFLLHL LEVGFLPDLR AAASLDTAAL SATDMALALN
     RYLCTAVLPL LTRCAPLFAG TEHHASLIDS LLHTVYRLSK GCSLTKAQRD SIEECLLSIC
     GQLRPSMMQH LLRRLVFDVP LLNEHAKMPL KLLTNHYERC WKYYCLPSGW GNFGAASEEE
     LHLSRKLFWG IFDALSQKKY EQELFKLALP CLSAVAGALP PDYMESNYVN MMEKQSSMDS
     DGNFNPQPVD TSNITIPEKL EYFINKYAEH AHDKWSMEKF ANGWTYGETF SESAKVQPLM
     KQYKLLSEKE KEIYRWPIKE SLKTMLAWGW RIERTREGDS MALYNRTRRI SQTSQISVDT
     AHGYTPRAID MSNVTLSRDV HAMAEMMAEN YHNIWAKKKK LELEAKGGGN HPLLVPYDTL
     TAKEKAKDRE KAQDILKFLQ INGYVVSRGL KDLELDTPSI EKRFAYSFLQ QLIRYVDEAH
     QYILEFDGGS RGKGEQFPYE QEIKFFAKVV LPLIDQYFKN HRLYFLSSAS RPLSSGGHAS
     NKEKEMVTSL FCKLGVLVRH RISLFGNDAT SIVNCLHILG QTLDARTVMK TGLESVRMAL
     RTFLDNAAED LEKTMENLKQ GQFTHSRNQP KGVTQIINYT TVALLPVLSS LFEHIGQHQF
     GEDLILEDVQ VSCYRILASL YALGTSKSIY VERQRSALGE CLAAFSGAFP VAFLETHLNK
     HNIYSIYNTK NARDRAVLNL PTSVEKVCPN IPSLMKLMEE IVELAESGIR YTQMPHIMEV
     ILPMLCSYMS HWWEHGPENN PDKAEMCCTA LTSEHMNTLL GNILKIIYNN LGIDEGAWMK
     RLAVFSQPII SKAKPQLLKT HFLPLMDKLK KKAAVVVSDE EHLRAEGRGD MSEAELLILD
     EFTTLARDLY AFYPLLIRFV DYNRAKWLKE PNPEAEELFR MVAEVFIYWS KSHNFKREEQ
     NFVVQNEINN MSFLISDTKS KMSKAAVSDQ ERKKMKRKGD RYSMQTSLIV AALKRLLPIG
     LNICAPGDQE LIALAKNRFS MKDTEDEVRD VIRSNLHLQG KLEDPAIRWQ MALYKDLPNR
     TEDSSDPEKT VERVLDIANV LFHLEQSCSF LKLFYVNSVE HPQRSKKAVW HKLLSKQRKR
     AVVACFRMAP LYNLPRHRAV NLFLQGYDKS WIETEEHYFE DKLIEDLAKP GEEPPEEDES
     LKRVDPLHQL ILLFSRTALT EKCKLEEDFL YMAYADIMAK SCHDEEDDDG EEEVKSFEEK
     EMEKQKLLYQ QARLHDRGAA EMVLQTISAS KGEMGPMVAA TLKLGIAILN GGNSTVQQKM
     LDYLKDKKDV GFFQSLAGLM QSCSVLDLNA FERQNKAEGL GMVTEEGSGE KVMQDDEFTC
     DLFRFLQLLC EGHNSDFQNY LRTQTGNNTT VNIIISTVDY LLRVQESISD FYWYYSGKDV
     IDEQGQRNFS KAIQVAKQVF NTLTEYIQGP CTGNQQSLAH SRLWDAVVGF LHVFAHMQMK
     LSQDSSQIEL LKELMDLQKD MVVMLLSMLE GNVVNGTIGK QMVDMLVESS NNVEMILKFF
     DMFLKLKDLT SSDAFKEYDP DGKGIISKRD FHRAMESHKH YTQSETEFLL SCAETDENET
     LDYEEFVKRF HEPAKDIGFN VAVLLTNLSE HMPHDTRLQT FLELSESVLN YFQPFLGRIE
     IMGSAKRIER VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGEKEKME LFVNFCEDTI
     FEMQLAAQIS ESDLNERSAN KEENDKDNPE EEDPRMGFFS LVTMKSALVA LKYNLMTLMK
     MLSMKSLKKQ MKKMKKMTMK DMVLALFSSY WSILVGLLHF ACSVVRGFFR IICSLLLGGS
     LVEGAKKIKV AELLANMPDP TQDEVRGEEE EGERKPTEAA LPAEDLTDLQ TLTEESDLLS
     DIFGLDLKRE GGQYKLIPHN PNAGLSDLLS TPSLAPMPEV QENIQVIKVK EDEKEEKEET
     KSEPEKAEGE DGEKEEKTKE DKGKQKLRQL HTHRYGEPEV QESVFWKNII AYQQKLLNYF
     ARNFYNMRML ALFVAFAINF ILLFYKVSTS AVTEEKELPV VSDGESTKLN ILESDDERVI
     AVHYVLEESS GYMEPTLRIL AILHTVISFF CIIGYYCLKV PLVIFKREKE VARKLEFDGL
     YITEQPSEDD IKGQWDRLVI NTQSFPNNYW DKFVKRKVMD KYGEFYGRDR ISELLGMDKA
     ALDFSDAREK KKPKKDSSFS AVLNSIDVKY QMWKLGVVFT DNSFLYLAWY MTMSVLGHYN
     NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA VVVYLYTVVA FNFFRKFYNK
     SEDGDMPDMK CDDMLTCYMF HMYVGVRAGG GIGDEIEDPA GDEYEIYRII FDITFFFFVI
     VILLAIIQGL IIDAFGELRD QQEQVKEDME TKCFICGIGN DYFDTVPHGF ETHTLQEHNL
     ANYLFFLMYL INKDETEHTG QESYVWKMYQ ERCWEFFPAG DCFRKQYEDQ LN
//
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