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Database: UniProt
Entry: H0ZKW7_TAEGU
LinkDB: H0ZKW7_TAEGU
Original site: H0ZKW7_TAEGU 
ID   H0ZKW7_TAEGU            Unreviewed;      1740 AA.
AC   H0ZKW7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 49.
DE   SubName: Full=Sodium leak channel, non-selective {ECO:0000313|Ensembl:ENSTGUP00000011239};
GN   Name=NALCN {ECO:0000313|Ensembl:ENSTGUP00000011239};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000011239, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000011239, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000011239}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTGUP00000011239}.
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DR   EMBL; ABQF01013249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01013250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01013251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01013252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01013253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01013254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01013255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01013256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01013257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01013258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59729.ENSTGUP00000011239; -.
DR   Ensembl; ENSTGUT00000011360; ENSTGUP00000011239; ENSTGUG00000010876.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H0ZKW7; -.
DR   OMA; MLGDSAM; -.
DR   OrthoDB; EOG091G00F9; -.
DR   TreeFam; TF312843; -.
DR   Reactome; R-TGU-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000007754; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    299    322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    385    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    506    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    577    601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    883    907       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    958    976       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1019   1042       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1136   1159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1213   1233       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1239   1258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1278   1296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1338   1360       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1425   1449       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36    331       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      384    605       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      889   1164       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1211   1459       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      800    829       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1740 AA;  200542 MW;  EDE6D5B66075F204 CRC64;
     MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPKT
     FEHYPPLQYV TFALDTLLMF LYTAEMIAKM HIRGIVKGDS SYVKDRWCVF DGFMVFCLWV
     SLVLQVFEIA EIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS
     VSIFLLFFLL LYGILGVQMF GTFTYHCVTD DTQPGNVTWN NLAIPDTHCS RELEEGYQCP
     PGFKCMDLED LGLSRQELGY SGFNEIGTSI FTVYEAASQE GWVFLMYRAI DSFPRWRSYF
     YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGSRS STTSTATTQM FHEDAAGGWQ
     LVAVDVNKPQ GRAPACLQKM MRSSVFHMFI LSMVAVDVIV AASNYYKGEN FKRQYDEFYL
     AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVIG TTLHIYPDLY HSQFTYFQVL
     RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF
     PRASAFMSMF QILTQEGWVD VMDQTLNAVG HMWAPVVAIY FILYHLFATL ILLSLFVAVI
     LDNLELDEDL KKLKQLKQSE ANADTKEKLP LRLRIFEKFP NRPQMVKISK LPSDFTVPKI
     RESFMKQFID RQQQDTSCLL RRLPSASSSS CDHSKRSAIE ENRYIDQKLR KSVFSIRARN
     LLEKETAINK ILRACTRQRM LSGSFEGQPA KERSILSVQH HIRQERRSLR HGSNSQRISR
     GKSLETLTQD HSNTVRYRNA QREDSEIKMI QEKKEQAEMK RKVQEEELRE NHPYFDKPLF
     IVGREHRFRN FCRVVVRARF NASKTDPVTG AVKNTKYHQL YDLLGLVTYL DWVMIIVTIC
     SCISMMFESP FRRVMHAPTL QIAEYVFVIF MSIELNLKIM ADGLFFTPTA VIRDFGGVMD
     IFIYLVSLIF LCWMPQNVPA KSGAQLLMVL RCLRPLRIFK LVPQMRKVVR ELFSGFKEIF
     LVSILLLTLM LVFASFGVQL FAGKLAKCND PHIISREDCH GIFRINVSVS KNLNLKLRPG
     EKKPGFWVPR VWANPRNFNF DNVGNAMLAL FEVLSLKGWV EVRDVIIHRV GPIHGIYIHV
     FVFLGCMIGL TLFVGVVIAN FNENKGTALL TVDQRRWEDL KSRLKIAQPL HLPPRPDNDG
     FRAKMYDITQ HPFFKRTIAV LVLAQSVLLS VKWDAADPVT VPLATMSVVF TFIFVLEVTM
     KIIAMSPSGF WQSRRNRYDL LVTSLGVIWV ILHFALLNAY TYMMGACVIV FRFFSICGKH
     VTLKMLLLTV VVSMYKSFFI IVGMFLLLLC YAFAGVVLFG TVKYGENINR HANFSSAGKA
     ITVLFRIVTG EDWNKIMHDC MVQPPFCTPD NSTYWKTDCG NYAGALMYFC SFYVIIAYIM
     LNLLVAIIVE NFSLFYSTEE DQLLSYNDLR HFQIIWNMVD DKREGVIPTF RVKFLLRLLR
     GRLEVDLDKD KLLFKHMCYE MERLHNGGDV TFHDVLSMLS YRSVDIRKSL QLEELLAREQ
     LEYTIEEEVA KQTIRMWLKK CLKRIRAKQQ QSCSIIHSLR ESQQQELSRF LNPPSIETTQ
     PSEDMNALNQ DNSAQPETSS QQQLLSPTLS DRGGYRQDTG DAGKPQRKFG QWRLPSAPKP
     ISHSVSSVNL RFGGRSTMKS VACKMNPMSD AASCGSEVKK WWTRQLTVES DESGEDLLDI
//
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