ID H0ZP56_TAEGU Unreviewed; 3164 AA.
AC H0ZP56;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=DNA polymerase zeta catalytic subunit {ECO:0000256|ARBA:ARBA00021589};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=REV3L {ECO:0000313|Ensembl:ENSTGUP00000012386.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000012386.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000012386.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000012386.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR STRING; 59729.ENSTGUP00000012386; -.
DR Ensembl; ENSTGUT00000012524.2; ENSTGUP00000012386.2; ENSTGUG00000012020.2.
DR GeneTree; ENSGT00940000156226; -.
DR HOGENOM; CLU_000203_1_0_1; -.
DR InParanoid; H0ZP56; -.
DR OMA; DPTSWIR; -.
DR OrthoDB; 211439at2759; -.
DR TreeFam; TF101072; -.
DR Proteomes; UP000007754; Chromosome 3.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:Ensembl.
DR CDD; cd05778; DNA_polB_zeta_exo; 1.
DR CDD; cd05534; POLBc_zeta; 1.
DR CDD; cd22287; REV3L_RBD; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR032757; DUF4683.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR025687; Znf-C4pol.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 2.
DR Pfam; PF15735; DUF4683; 1.
DR Pfam; PF14260; zf-C4pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 93..188
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 745..1135
FT /note="DUF4683"
FT /evidence="ECO:0000259|Pfam:PF15735"
FT DOMAIN 2184..2518
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 2584..3034
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 3076..3143
FT /note="C4-type zinc-finger of DNA polymerase delta"
FT /evidence="ECO:0000259|Pfam:PF14260"
FT REGION 434..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1317..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1364..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1550..1622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1697..1730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1856..1884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1972..1998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2076..2179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1063
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1324..1347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1706..1721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1856..1883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2085..2131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2158..2175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3164 AA; 356389 MW; CDF4E3C69381430C CRC64;
MFSVRIVTAD YYMGSPLPGL DPCQSRFREA PAKRVPVVRV FGATPAGQKT CLHLHGIFPY
LYVPYDGFGQ HPECYLRQVA FSIDRALNVA LGNPSSTVQH VFKVSLVSGM PFYGYHEKER
QFMKIYLYNP AMVKRVCELL QGGAIMNKSY QPHEAHIPYL LQLFIDYNLY GMNLINLAAV
KFRKARRKGD TSGVSKHHRT HLPENSSNVS FIEWEEDEIP SSLMLKGVEP QSTCELEVDA
VAADILNQLD IEAQIGRNPG LQAIWEDEKQ RRRQKCESSQ IKPPESQDRG FVPATESEKF
FQKRLKEILK QNDFSVTLSG SLDYSNGSEE FSAELTLHSE VLSAEAFPCT PANTVEVHDD
KQMSKDSKSV HTDKEEALIN EEAILNIVEN SQSFQPLSQR LNQTTVFMGS SADEAMIDLL
AGLENDGYQM GHQKTLSHHR SLGSWRTSQN SDDEENEPQC EKEEMELSLL MSQRWDSSME
EPGQKRRSAS KNMHRSSTEE DSSSEEEMEW SSNNMLLTNL SIPQLDGTAD ENGDNPLNNE
SSRTHSSVIA TSKMSVKTSI FHKDAATLEP PSSAKITFQC KHTSALSNHV LNNEDFVEDL
SQPNTETRPE LSVHSLTKES TYSAKYPTPF SNSTHAENSH KESNKKDTLS VPSCGNNIFD
YEDDISSVNR PIPSRKYISI RKAEKDVSFV HVGRHIGDNM LNKNLYNFSD MSHSKGKMSS
EVNEKSSSAS INSFFPATAT ENCELVSCSG GSRTVVHSLE NNTDEGGLNK LKIRYEEFQE
HKAEKPSLSQ QAAHYMFFPS VVLSNCLSQP QKLAPVTYKL QQGNKQSRLK LSKKKHSFIN
RQEPATANDV ASVKEVCYTQ GNACSNIPDK DSALPSDLVQ VPLEAFENKM PTSTANYTDC
QFADGSLETE QSFGLCGNKY TLRTKRKVNY ETEDSESSFV AHNSKINLPQ PIESVESMDG
SQKSRKRRKL SKKLPPVIIK YIIINRFRGR KNMLVKLGKV DSSEERVVLT EEKMNLYKKL
APLKDFWPKV PDSPATKYPI YPLTPKKSHK RKAKHKSTKK KAGKPQKTGS TNIKRTLSFR
KRTHAILSPP SPSYSAEAED CDYNYSDVMS KLGFLSERST SPVNTSPPRC WSPTDPKAEE
ILTNLDREAL FSRGPNIYNS KTVNTSVGKT SRAKTQVKKC KKKFSSPTVS TKKKKKINQV
DKTPDDGKKK PRAKQKMAEK ASSRKRVVFK DEKGSSRSTT EVKFVLKHQD PHEISYNSIC
SQPLHNLKDS PLPGYSAGYL PSAQLPSADA QRNSSGCFHS LMEIDKPVDA QCLPAPREDP
HSSFASTPVA SGREVPKMST QRSRTQSAVF RMKDSALIQN IFDPSNHSTH MTQNAHISKD
KTPPKAEEIK NLQIRYLPPA GKLNETRDSL DTVKMDQLHT TNYLHCKDSN QQQVFCLPEA
SKHSDPCSSI LKPSEENPGP LQLPKTCFVT SLKSPVKQLN CDQNQRGFIL DMSHFKPETT
KQRPLSEATM QPKPISQYKN RNIVAPSAFG EGQSGLAVLK ELLQKRQQKA QNASIAQEPL
PDKPQLSKGI PCPLEQNKAI KRSRPVTLSR KSRSPRSTKP KEKTAKLAKM ESSSQPITHR
IDHSVSNDSP IFFSDPGFES CYSLEDSLSP DHNYNFDINT IGQSGFCSFY SASQFVPADQ
NLPQKFLSDA VQDLGSGQTA ESDFLSHNDQ KSEEEKQHSS STNKWMRPGS LSPELFEKTS
LENSENHCHS QWRKTIHSSA ARSSFIDTSC TQETEVCLNE KFKLNRNTVN KERFLNLSQP
ACSDWIQSHI RKETTFEPCQ PLDSINTSFT SLLSSPDGEL LDAASEDLEL HVSRNNEVLT
PTPDSSPRST SSPSQSKNGS FTPRTAHILK PLMSPPSREE IMATLLDHDL AETVYQEPFC
SNPSDAPEKP REIGGRLLTV ETRLPNDLLE FEGDFSLEGL RLWKTAFSAM TESPRPVSPP
HYGHSTVNKR ESNSHKTSED KKIVIMPCKC APSQQQVQMW LHAKEEYEHF KKLPKSHSAE
LAKADENFSS AVLSEEKSIE VIKVAKDLNL SSLEDERPIV PTKNSPASVA ENTKMQTKET
CDKSISNIRT SVNTKNDIDS NKTSCASKTH TTSALEHDKE EEEEEEEDYY VSYSSPDSPV
LPPWQQVASP DPKQSSLEDT EWKNQDILSF VEGSDVGSAQ NSPCTQENIR TSFDISPFPV
NEDPGNSESV CLHSTPIVHR KSQDGMPEIL GFTPLSAEPK AQKLSHKRGI NTDGLRRVLL
TTQMKNQFAA LGAPKKETSQ IEGPSLNNTY GFKVSVENLQ EAKSLHEVQH LTLISMELHA
RTRRDLEPDP EFDPICALFY CISSDSALPN TDKKEITGAI VIDRGRTLSS QGSRDQAPLL
TRSGVTGLEV SYATDERTLF QEVVNIVKRY DPDILLGYEV QMHSWGYLLQ RAEALNVDLC
QMISRVPDKS KENRFATELD EYGADTMSEI NIVGRIVLNI WRMMRHEVTL TNYTFENVGF
HVLHHRFPLF TFRVLSDWFD NKADVYRWKM VDHYVSRVRG NLLLLEKLDL IDRTSEMARL
FGIQFLHVLT RGSQYRVESV MLRIAKPMNY IAVTPSVQQR AQMKAPQCVP LIMEPESRFY
SNAVLVLDFQ SLYPSIVIAY NYCFSTCLGH VENLGKYDAF KFGCTSLRVP PDLLYQIRHD
ITVSPSGVAF VKPSVRKGVL PRMLEEILKT RIMVKQSMKA YKHDKAVTRM LEARQLGLKY
IANFTFGYTA ANFSGRMPCT EIGDSIVHKA RETLERAIKL VNDTKKWGAH VVYGDTDSMF
VLLKGATKEQ SFKIGQEIAE AVTATNPKPV KLKFEKVYLP CVLQTKKRYV GYMYETLDQK
DPVFDAKGIE TVRRDSCPAV SKILECSIKL LFETRDISQI KQYVQNQCMK LLEGKASMQD
FIFAKEYRGS SAYKPGACVP ALEITRRMLA YDRRSEPRVG ERVPYVIVYG TPGLPLIQLV
RRPLEVLQDP SLRLNATYYI TKQILPPLAR VFSLIGIDVF SWYHELPRIQ KAASAARTEL
EGRKGTISQY FTTLHCPVCD ELTQYGICNK CRSQPQHVAV ILNQEIRELE RKQEQLVQIC
RNCTGCFDRQ IQCVSLNCPV LFKLSRVSRE LSKAPYLRQL LDQF
//
