ID H0ZRL2_TAEGU Unreviewed; 4580 AA.
AC H0ZRL2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=FAT atypical cadherin 3 {ECO:0000313|Ensembl:ENSTGUP00000013256.2};
GN Name=FAT3 {ECO:0000313|Ensembl:ENSTGUP00000013256.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000013256.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000013256.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000013256.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 59729.ENSTGUP00000031890; -.
DR Ensembl; ENSTGUT00000013406.2; ENSTGUP00000013256.2; ENSTGUG00000012873.2.
DR GeneTree; ENSGT00940000154981; -.
DR HOGENOM; CLU_000042_1_0_1; -.
DR TreeFam; TF316403; -.
DR Proteomes; UP000007754; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 34.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 34.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF00028; Cadherin; 26.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 14.
DR PROSITE; PS50268; CADHERIN_2; 32.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..4580
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025592262"
FT TRANSMEM 4179..4199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..158
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 159..266
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 377..473
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 474..579
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 588..682
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 728..832
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 833..937
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 938..1044
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1052..1149
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1150..1255
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1256..1360
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1364..1484
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1485..1590
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1591..1793
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1794..1907
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1923..2010
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2007..2108
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2109..2210
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2211..2311
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2312..2418
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2419..2520
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2521..2624
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2625..2732
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2733..2838
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2839..2948
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2949..3053
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3054..3155
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3156..3260
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3261..3365
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3366..3470
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3471..3575
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3586..3677
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3819..3857
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3859..4042
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4045..4082
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4084..4120
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4122..4158
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4349..4371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4421..4525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4488..4522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 4072..4081
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4110..4119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4148..4157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4580 AA; 504584 MW; 4313A1FB08F8E5B3 CRC64;
MDVNMGRWSG SRLPPSCLAL LIVKFLASIC QVAHGTALLG FHFTHSTYNA TVYENSAART
YVNSQTRMGI TMADLSWDIK YKIVSGDDEG FFKAEEVIIA DFCFLRIRTK GGNSAILNRE
IQDNYLLMVK GSVRGEDLEA WTKVNIQVLD MNDLRPLFSP TTYSVTIAES TPLRTSIAQV
TATDADIGSN GEFYYYFKGK VELFSVHPTS GVISLSGRLN YDEKNRYDLE VLAVDRGMKL
YGNNGVSSTA KLYVHIERIN EHAPTISVVT HIPFPSDKEP TYAVVNVDDL DEGANGEIES
VSIVAGDPLE QFFLSKEGKW MNEYKIKERK PIDWDSFPYG YNLTLQAKDK GSPQKFSAVK
LVHIASPKKE SIPLKFEKEA YDIFISEFSP PGVVVAVVKL MPEPQGVEYR ISPSEEAEYF
KINPNTGLIT TARSLKIIDK DLYELEVYAN KGGDLKAQVT VRLEDANDHT PEFQQLSYSS
FVNESVPVGS SVLAVSAVDE DRGENGYITY SIASLNSLPF TINQFTGVIS TSEELDFESS
PESYRFIVRA SDWGSPYRHE SEVNVTIYIG NVNDNKPLFE KVACQGVISS DFPVGGHITA
VSAIDIDELE LVKYKIISGN ELGLFYLSPD SGVLQLKKSL VNSGIKNNNF GLKITATDGE
NFADAMFVNI SVVHGKVSSK TFSCRETRVA QKLAEKLLKK AKANVKLNLE DGFLDFYSVN
RQAPHFDKSF PADVKVSEDL PVGATILRIK AYDADSGFNG RVLYTISDGN VDSCFNIDME
MGILSVLMPL DREKTELYLL NITIYDLGNP QKSSWRLLTV TVEDANDNKP VFLQDSYSVN
ILESTSLGTE IIQVEARDKD LGSNGEVTYS VLTDTHQFAI NSSTGVVYVA DQLDREAKAN
YTLKIEARDR AESGHQQFSV VPLKVFLDDV NDCSPAFIPS SYNVKVLEDL PVGTVIAWLE
THDPDLGLGG QVRYSLVNDY NGRFEIDKAS GAIRLNKELD YEKQQFYNLT VRAKDKGRPV
SLSSLSFVEV EVVDVNENLY TPYFPDFAVI GSVKENSRIG TSVLQVVARD EDSGRDGEIQ
YSIRDGSGLG RFSIDEETGV IYTADVLDRE TTKSYWLTVY ATDHGVVPLY TTMEVYIEVE
DVNDNAPLTS EPIYYPVIME NSPKDVSVIQ IQAQDPDSST NEKLTYRITS GNPQNFFVIN
PKTGLITTTS RKLDREQQAE HFLEVTVSDG GASPKQSSVW VVVQVLDEND NKPQFPEKVY
QIKLPERDRK KRGEPIYRAF AFDKDEGPNA EISYSIVDGN DDGKFFIDPK TGMVSSRKQF
TAGSYDILTI KAVDNGRPQK SSTARLHIEW IKKPVPSPVP LTFDEPFYNF TIMESDKVTE
IVGVVSVQPS NIPLWFDIVG GKHAREMFYI LQTACGQNCS TEGGNYDSSF DVYKGVGTIV
IAKPLDAEQR SMYNMTVEVT DGTNIATAQV LIKVLDNNDN GPEFSQPSYD VTISEDILPD
TEILQIEAID RDEKHKLSYT IHSSIDTVSM RKFRIDPNTG VLYTAERLDH EAQDKHILNV
MVRDQEFPYR RNLARVIINV EDSNDHSPYF TSPLYEASVF ESAAVGSAVL QVTALDKDKG
ENAELIYTIE AGNTGNTFKI EPVLGIITLL KEPDLTTMGQ FVLSVKVTDQ GSPALSATAI
VRISVTMADN SHPKFTLKEY QAEVNENVDI GTSVISLSAI SQSTLVYEVK DGNVDGVFTI
NPYSGVITSQ KALDYEHASS YQLIVQATNM AGMASNATVN IQIVDENDNP PVFLFSEYSG
SISEAAPVNS VVRSANNSPL VIRATDADSN QNALLVYQIV ESTAKKYFTV DSSTGAIRTI
ANLDHETIAR FHFHVHVRDS GNPQLTAESP VEVTIEVTDV NDNPPVFSQA VFETVLLLPT
YIGVEVLKVK ASDPDSEIPP ELTFSIIEGN MDHFLIDSST GVLTIKNNSL SKDHYMLIVR
VSDGKFYSTA MVTIMVKEAM DSGLHFTQNF YSTSISENST NITKIAVVNA VGNRLNEPLK
YSILNPGNKF KIKSTSGVIQ TTGIPFDREE QELYELVVEA SRELDHLRVA RVVVRVYIED
INDNAPVFVG LPYYAAVQVD AEPGTLIYRV TAIDKDKGDN GEVSYLLRED YGHFEIDRGS
GSITLKETFN SDLSNIEYLV VILAKDGGSP SLSASIELPI TIVNKAMPVF DKPFYTASVN
EDVEMHMPIL SINATSPEGQ GIIYIIVDGD PYNQFNIDFD TGVLSVISPL DYEINSLFKL
MVRASDSLTG ARAEVTVDLI VNDVNDNPPV FDQSAYNATL SEASLIGTPV LQVVATDADS
DNNKIVQYQI VQDTFNSTDY FHIDSSSGLI LTARMLDHEL IQQCSLKVRA TDNGFPPLSS
EVLVSISITD MNDNPPVFNQ LIYESYVSEL APRGHFVTCV QASDADSSDF DRLEYSILSG
NDRTSFIMDS KSGVITLSNH RKQRMEPMYS LNVSVSDGLF TSTAQVHIQI LGANLYSPVF
SQSIYVAEVR ENAAPGTKVI HVKATDGDSG VYGQISYSII NDFAKDRFLI DANGQIMTTE
RLDRENPLES DVDIFLRALD GGGRTTFCTV RVIVVDENDN APKFMAVEYR ASVKADVGKG
YLVTQVQAVD PDDGANSRII YSLYSEASVS VADLLEIDPD NGWMVTKGSF NQLKNTVLSF
FVKAIDGGIP VKHSLIPVYI HVLPPETILP SFSQPQYSFT VAEDTLIGST IDILHVLPNQ
GALYSTVNGE LPENNKDGVF IIEKDTGLIK LDKRLDHEIN SAFHFKVAAT IQLDKVDIVL
TVDVEVKVLD VNDNKPVFEA ANYDAVIMEG MPIGTKLMQV KAVDADSSAN GQVTYTLEVE
SELQKITEAF TIDSNSGWIS TLKDLDHEKD SAFTFAVVAS DLGEALSLSS TTLVSVTVTD
INDNAPVFEH EVYRGSVKES DPPGEVVAVL STWDEDTSDV NRQVSYHITG GNPKGKFSLG
LVQNEWKVYV KRPLDREEQD IYYLNITATD GLFVTQAAVE VTVTDVNDNN PVCEQVAYTA
LFPEDIPPNK VILKISAKDA DIGSNGEIRY SLYGSGNNKF FLDPENGELK SLAPLDREKI
PAYNLVARAT DGGGRFCQSE IHLILEDVND NPPVFSSDHY TACVYENTAT KALLTRVQAT
DPDVGVNRKV TYSLSDSADG YFSVDRSSGI IILEHPLDRE LQSSYNITVK ASDQSIVLTL
SSFATVTITV LDINDNPPVF ERRDYLVTVP EDTSPGTEVL SVFATSQDIG TNAEIAYLIR
SGNEKGKFRI NSKTGVISII EALDFESCKD FYLVVEAKDG GTPALSAVTT VNVNVTDVND
NAPTFSQAVY SAVISEDAAV GDSVVMLIAE DLDSPPNGQI HFSIVNGDQD NEFSVDPVLG
LVKVKKKLDR ERISGYSLVV QARDSGTPPL SSSVTVNVDI SDVNDNSPVF TPANYTAVIQ
ENKPVGTSIL QLVVTDKDSF HNGPPFTFTI LTGNEEEEFT LDPHGVLRSA VIFKHMVSTE
YVLCVQAKDS GKPQQVSHTY VQVRVIEESI HKPTAIPLEI FIVTMEDDFP GGVIGKIHAT
DQDVYDVLTY TLKSEQKSLF KVNSHDGKII ALGGLDNGKY ILNVSVSDGR FQVPIDVVVH
VEQLLQEMLQ NTVTIRFENV SPEDFVGLHM HGFRRTLRNA VLSQKQDSLH IISIQPVAGS
SQLDMLFAVQ MHSGGFYKPA YLIQKLTNAR RHLENVIRIS AILEKNCSGL DCQEQHCEQS
LSIDSHSLMT YSTARISFVC PRFYRNVRCM CNGGLCPGSN DPCLEKPCPG DMQCVGYEAN
RRPFICQCPP GKLGECSGHT SLSFAGNSYI KYRVSENSKK EEFKLALRLR TLQSNGIIMY
TRANPCIILK IVDGKLWFQL DCGSGPGILG ISGRAVNDGS WHSVFLELNR NFTSLSLDDS
YVERRKAPLY FQTLGTDSSV YFGAQVQVDN VRSLTDKRTT QVLSGFQGCL DSVVLNNNEL
PLQNKRSSFA EVVGLTELKL GCVLYPDACE RHPCQNGGTC TAVPSGGYHC NCLSQFTGRN
CESEITACFP NPCRNGGSCD PIGNAFICNC KNGLTGVTCE EDINECEREE CENGGSCVNI
FGSFLCNCTP GYVGQYCGLR PVVVPNIQAG HSYVGKEELI GIAVVLFVIF VLIVLFIIFR
KKVFRKNYSR NNITLVQDPA TAALLNKSNG IQFKNIRNSG DSRNIYQEVG PPQVPVRPMA
YTPCFQSDSR NNLDKIVDGL GVEHQEMTTF HPESPRILTA RRGVVVCSVA PNLPAVSPCR
SDCDSIRKST WDAGTESKGV DDAEEVTCFS GSNKGSNSEV QSLSSFQSDS GDDNAYHWDT
SDWMPSARLS DIEEVPNFET ADGGSAHHGS TRELETDYYL GGYDIDSDYP PPHEEEFLSQ
DQLPPPLPED YPDQYETLPP SQPGSMASTL SPDCRRRPHF HPSQYLPPHQ FPNETDTTGS
QTGNEFSTFA AGPSQNTENA GAGKMPLSLH NSLNASSSDV SAGCGFDDSE VAMSDFESME
ELSLENVHIP FVETQQQTQV
//
