ID H0ZVG9_TAEGU Unreviewed; 1214 AA.
AC H0ZVG9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000014616.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000014616.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000014616.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR AlphaFoldDB; H0ZVG9; -.
DR STRING; 59729.ENSTGUP00000014601; -.
DR Ensembl; ENSTGUT00000014812.2; ENSTGUP00000014616.2; ENSTGUG00000014232.2.
DR GeneTree; ENSGT00940000155826; -.
DR HOGENOM; CLU_020535_0_0_1; -.
DR Proteomes; UP000007754; Chromosome Z.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd06007; R3H_DEXH_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034083; R3H_DEXH_helicase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 113..181
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 277..433
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 560..592
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 659..838
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1214 AA; 135301 MW; 7F0F149C8CA32DB7 CRC64;
MTGQVPVPRF ARSHTPSPGL GQPCPRTGGK SANFLPFGPA RLRASPAPPQ RRPSGRAAAV
PDPRRCRGRV GAAWGRVGDM SRHRRVPRRQ PGGAAEDGAA AAAVRARAEP LREAGVDEEV
EMAVQLALER FQSGDEAEME FPSSFTSTER AFVHRLCQSL GLVSKSKGKG ANRYLTVRKK
DVSEAHVVMT CDLALRTKHA VRSLIQRFPV TNKERKELLP RTERGSVCAV ASENKEVNKT
SGRLNDGIPQ VPVKRGESEF DSFRQSLPVL EKQEEIVQII RDNKIVLVIG ESGSGKTTQI
PQFILDDCYK NGTPCRVFCT QPRRLAAVAV AERVAAERRE KIGQTIGYQI RLENSHILRP
LCDPESVMVF HLFFPLLLQD EVHERDRFSD FLLIKLRDVL QNQNNLKLIL SSAALDANLF
IRYFGSCPVI HIQGRPFQVK EMFLEDILRS TGYANKEMVK YKEKKQQGHH LKSVFYSCVE
SLRTVTYFKD YLIRMNCSTF NIVFYLQTEK DVNCLEPWIV KEMDSCLSDI WLHKDIDLFA
QLLNLILTEN VSVDYRHSET GATALMISSG RGFLSQVEQL ISMGASIHCK SSNGWMAVDW
ARHFGQTEVV HLLESYSASF GFGNMDESSL VQKSASDLSA EDRELLTAYH HSFDDEKVDL
DLIMHLLHSI CHSSDAGAIL IFLPGYDEIV SLRDRIVLDD KRFTDNAHRY QVFVLHSSMQ
TLYQKKVLES PPFGIRKIIL STNIAETSIT VSDVVFVIDS GKVKEKSFDA LSRVTMVKMG
WISKASAIQR KGRAGRCQPG VCFRLFSRLR FQNMLEFQSP ELLRMPLQEI CLYTKLLAPV
NCPIVDFLMK APDPPPAVTV RNAVHMLKTI DAMDPWEDLT ELGYHLTELP VEPHLGKMVL
YAVVLKCLDP VLTIACALAC QDPFVLPTLA SQKRAAVLCR KRFAAGTFSD HMALLRAFQA
WQKARSEGWE RAFCEKNFLS QATMETIAGM RTQVLGQLRA SGFVRARGGA DIRDVNTNSE
NWAVIKGALV AGMYPNLVHV DRDSLVLTES KEKKVRFHPT SALGQSQYKK IAPANGQAAA
IQALPTDWLI YDEMTRAHKT ANIRCCSVVT PVTVALFCGP ARLPSNALQA SSSFRGGGVS
NDSSDSEMED KTSADLALLK LDEWLHLRLD PEVSKKLLLG LLHGPSAPSG LLSCLHGAPS
GHSTSWDSQN LNRS
//
