ID H1AGA6_URSTH Unreviewed; 203 AA.
AC H1AGA6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Liver type phosphofructokinase {ECO:0000313|EMBL:BAL46045.1};
DE Flags: Fragment;
GN Name=PFKL {ECO:0000313|EMBL:BAL46045.1};
OS Ursus thibetanus japonicus (Japanese black bear).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=378754 {ECO:0000313|EMBL:BAL46045.1};
RN [1] {ECO:0000313|EMBL:BAL46045.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:BAL46045.1};
RA Shimozuru M., Kamine A., Tsubota T.;
RT "Changes in expression of hepatic genes involved in energy metabolism
RT during hibernation in captive, adult, female Japanese black bears (Ursus
RT thibetanus japonicus).";
RL Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 163:254-261(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-
CC bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634,
CC ChEBI:CHEBI:456216; EC=2.7.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00000432};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004679}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB693175; BAL46045.1; -; mRNA.
DR AlphaFoldDB; H1AGA6; -.
DR UniPathway; UPA00109; UER00182.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003872; F:6-phosphofructokinase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.450; -; 1.
DR Gene3D; 3.40.50.460; Phosphofructokinase domain; 1.
DR InterPro; IPR022953; ATP_PFK.
DR InterPro; IPR000023; Phosphofructokinase_dom.
DR InterPro; IPR035966; PKF_sf.
DR PANTHER; PTHR13697:SF14; ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE; 1.
DR PANTHER; PTHR13697; PHOSPHOFRUCTOKINASE; 1.
DR Pfam; PF00365; PFK; 1.
DR PRINTS; PR00476; PHFRCTKINASE.
DR SUPFAM; SSF53784; Phosphofructokinase; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAL46045.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 42..202
FT /note="Phosphofructokinase"
FT /evidence="ECO:0000259|Pfam:PF00365"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAL46045.1"
FT NON_TER 203
FT /evidence="ECO:0000313|EMBL:BAL46045.1"
SQ SEQUENCE 203 AA; 22039 MW; ED858121371BADE2 CRC64;
AMDEKRFDEA IQLRGRSFEN NWNIYKLLAH QKVSKEKTNF SLAILNVGAP AAGMNAAVRS
AVRSGISQGH TVYVVHDGFE GLAKGQVQEV SWHDVAGWLG RGGSMLGTKR TLPKSYMEKI
VGNIRTHNIH ALLVIGGFEA YEGVLQLVEA RGRYEELCIV MCVIPATISN NVPGTDYSLG
SDTAVNAAME SCDRIKQSAS GTK
//
