ID H1LMI9_9PAST Unreviewed; 1108 AA.
AC H1LMI9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Putative potassium efflux system KefA {ECO:0000313|EMBL:EHO48761.1};
GN ORFNames=HMPREF9096_00484 {ECO:0000313|EMBL:EHO48761.1};
OS Haemophilus sp. oral taxon 851 str. F0397.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=762965 {ECO:0000313|EMBL:EHO48761.1, ECO:0000313|Proteomes:UP000005305};
RN [1] {ECO:0000313|EMBL:EHO48761.1, ECO:0000313|Proteomes:UP000005305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0397 {ECO:0000313|EMBL:EHO48761.1,
RC ECO:0000313|Proteomes:UP000005305};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHO48761.1}.
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DR EMBL; AGRK01000008; EHO48761.1; -; Genomic_DNA.
DR RefSeq; WP_009500064.1; NZ_JH591070.1.
DR AlphaFoldDB; H1LMI9; -.
DR PATRIC; fig|762965.3.peg.463; -.
DR HOGENOM; CLU_007829_3_0_6; -.
DR Proteomes; UP000005305; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF8; MECHANOSENSITIVE CHANNEL MSCK; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1108
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003551143"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 793..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 911..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..272
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 493..823
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 884..925
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 927..991
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 1001..1083
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT COILED 121..148
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 182..268
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1108 AA; 126130 MW; 28A2E3177DD83CD6 CRC64;
MKTSRFFTAL LATALIGWAT VHPTFAANKS KILLPTEQEL SADLADVQKM ADGDVKTALI
NELQTSLDLL QLIQTQQKNN EDLHDVLAHA DSEIKKNNAD LLAFKKQLEQ SKSVDYQAQN
LADLQATLSK LNAQQQETQT ALSKANTQLA GQSSISERAQ TSLTENLKRT QEINQQLADS
NLTKTLRQKN QIELQLIDLK NAYNQDLLKN SDQLTLLYQS RYDLLNARLQ LLQQQIVAIQ
EVINQKNLAQ TQNQVEQVQQ QQQNSAKNAY IQKELERNAE LSQYLLQQTE KTNILTQDDL
RMRNVFDSLT QTQHTIEEQI SALQGTLVLS RIIQQQKQKL PTNLNIQGLS KQIADLRVQI
FDITQKRNEL YDLDAYIAKV ESDEGEKFTY AEKTQLVNLL TERRKMSSDL IKSLNNQLNL
AISLELTQQQ ITQISDQIQS KLEQQSFWVK SNNPINLDWF TELPRAFIAQ VDGIVKKIGL
PTNYSNLPYL LMYCLGLFVV GGAIFKFKYR IKQRLSKING EINRLKYDNQ WNTPQALLLT
AFLTLSGTLW FLAICQMLGF FFMKNPTEFW DWSFSMAGYW WFFTFWLSLF RPNGIFVRHF
EFSQQSAVRF QSVIKRIVVA VVLLLNTSVF SNVTDYGLAN DVIGQVNTIV SLLFCIIIIA
PRFKNVLRSY EDEKKSHNHI IVKIVQFGLQ IIPVGLVILV ALGYYYTALN LIQHLINSYI
AWCVWWLIRQ VIYRGITVSS RRLAHRRLEE KLRQKQAGFN DGSTSDDVVV LNEKEEGLAL
NEVRSQLLRF ADLFIWTALI GIFYYVWSDL VAVASYLREV TLWQQTTTTE AGTVMESITL
FNLLVALVIV GITYVLVRNI SGILEVLIFS RVKLSQGTPY TITTLLTYVL VAVGGAWAFA
TLGMSWSKLQ WLFAALSVGL GFGMQEIFAN FVSGIILLFE RPIRVGDTVT INGVSGTVAK
IRIRAITLID FDRKEVIVPN KSFVTGQVIN WALSNTMTRL VINVGVAYGS NLELVKKLLL
QAANEQTTVL KDPEPRAYFL SFGASTLDHE LRVYVAQLAE RTNTIDALNR RINELFAENN
IDIAFNQLDV FIKNNDTGEE MPFIEVKK
//
