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Database: UniProt
Entry: H1SD33_9BURK
LinkDB: H1SD33_9BURK
Original site: H1SD33_9BURK 
ID   H1SD33_9BURK            Unreviewed;       596 AA.
AC   H1SD33;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-SEP-2017, entry version 37.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EHP39579.1};
GN   ORFNames=OR16_30774 {ECO:0000313|EMBL:EHP39579.1};
OS   Cupriavidus basilensis OR16.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=1127483 {ECO:0000313|EMBL:EHP39579.1, ECO:0000313|Proteomes:UP000005808};
RN   [1] {ECO:0000313|EMBL:EHP39579.1, ECO:0000313|Proteomes:UP000005808}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OR16 {ECO:0000313|EMBL:EHP39579.1,
RC   ECO:0000313|Proteomes:UP000005808};
RX   PubMed=22461549; DOI=10.1128/JB.06752-11;
RA   Cserhati M., Kriszt B., Szoboszlay S., Toth A., Szabo I., Tancsics A.,
RA   Nagy I., Horvath B., Nagy I., Kukolya J.;
RT   "De Novo Genome Project of Cupriavidus basilensis OR16.";
RL   J. Bacteriol. 194:2109-2110(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EHP39579.1}.
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DR   EMBL; AHJE01000087; EHP39579.1; -; Genomic_DNA.
DR   RefSeq; WP_006161854.1; NZ_AHJE01000087.1.
DR   EnsemblBacteria; EHP39579; EHP39579; OR16_30774.
DR   PATRIC; fig|1127483.3.peg.6140; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000005808; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005808};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005808}.
FT   DOMAIN      293    427       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      504    573       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     301    308       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   596 AA;  65388 MW;  6B8733F9D855682F CRC64;
     MQDFWQAAAA QLERELTPQQ FKTWIKPLAP VAFDEEAHAL RIAAPNRFKL DWVKSQFSGR
     ITALACEYWE ANVSVHFVLD PAASGRAAAG YPQQPGQAGQ PGQPGMAPQH AGPGYPSGQP
     LSQNFGQPGM QPGQGGQGYG PMNQGGGQRG GQAPYPGNGG GGNYPGNASQ ANMGGMGGEI
     VDIDVPQLDP AEASARSYRV QPAQQPMQGG HPGNQGGHPG HQGHQGHQAH QGHPGHPGHQ
     GHPGNQQGGQ QNDSVHERSR LNHILTFDNF VTGKANQLAR AAAIQVANNP GKSYNPLYLY
     GGVGLGKTHL IHAIGNFMLL ENPRARIRYI HAEQYVSDVV KAYQRKAFDE FKRYYHSLDL
     LLIDDIQFFS GKNRTQEEFF YAFEALIANR AQVIITSDTY PKEISGIDDR LISRFDSGLT
     VAIEPPELEM RVAILMKKAA AENVSVPEEV AFFVAKHLRS NVRELEGALR KILAFSNFHG
     KDITIDVTRE ALKDLLTVQN RQISVENIQK TCADFYNIKV ADMYSKKRPA NIARPRQIAM
     YLAKELTQKS LPEIGELFGG RDHTTVLHAV RKIADERSKD AQLNHELHVL EQTLKG
//
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