ID H1VX96_COLHI Unreviewed; 2495 AA.
AC H1VX96;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:CCF44858.1};
GN ORFNames=CH063_00531 {ECO:0000313|EMBL:CCF44858.1};
OS Colletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum destructivum species complex.
OX NCBI_TaxID=759273 {ECO:0000313|EMBL:CCF44858.1, ECO:0000313|Proteomes:UP000007174};
RN [1] {ECO:0000313|Proteomes:UP000007174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMI 349063 {ECO:0000313|Proteomes:UP000007174};
RX PubMed=22885923; DOI=10.1038/ng.2372;
RA O'Connell R.J., Thon M.R., Hacquard S., Amyotte S.G., Kleemann J.,
RA Torres M.F., Damm U., Buiate E.A., Epstein L., Alkan N., Altmueller J.,
RA Alvarado-Balderrama L., Bauser C.A., Becker C., Birren B.W., Chen Z.,
RA Choi J., Crouch J.A., Duvick J.P., Farman M.A., Gan P., Heiman D.,
RA Henrissat B., Howard R.J., Kabbage M., Koch C., Kracher B., Kubo Y.,
RA Law A.D., Lebrun M.-H., Lee Y.-H., Miyara I., Moore N., Neumann U.,
RA Nordstroem K., Panaccione D.G., Panstruga R., Place M., Proctor R.H.,
RA Prusky D., Rech G., Reinhardt R., Rollins J.A., Rounsley S., Schardl C.L.,
RA Schwartz D.C., Shenoy N., Shirasu K., Sikhakolli U.R., Stueber K.,
RA Sukno S.A., Sweigard J.A., Takano Y., Takahara H., Trail F.,
RA van der Does H.C., Voll L.M., Will I., Young S., Zeng Q., Zhang J.,
RA Zhou S., Dickman M.B., Schulze-Lefert P., Ver Loren van Themaat E.,
RA Ma L.-J., Vaillancourt L.J.;
RT "Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered
RT by genome and transcriptome analyses.";
RL Nat. Genet. 44:1060-1065(2012).
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DR EMBL; CACQ02007235; CCF44858.1; -; Genomic_DNA.
DR STRING; 759273.H1VX96; -.
DR EnsemblFungi; CCF44858; CCF44858; CH063_00531.
DR VEuPathDB; FungiDB:CH63R_13251; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR Proteomes; UP000007174; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..426
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2406..2485
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 36..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2495 AA; 272530 MW; EE713770050DC603 CRC64;
MSVPEPIAIC GIGLRLPGGI DTPTSLYNFL VNRKDARSKP DKPRYSSQTH HFTESGTTRP
LPTEEGYWLT HDDVTKFDPS MFSMNPKELS KLDPQQRLLL QVVWEALESA AETDWQGQRI
GCYVGSFGDD WREMHAVDTQ DDGMYRLTGY MDFVQANRIS HAFDLRGPSM TVRTACSAAG
LAVHLACQAI RAGECDSAVV AGSNLMLSPG FTKLMAEQSV LSPDASCKTF DAGANGYARA
EAVNCLFVKR LHCAIRDGNP IRAVIRGSAT NSDGKTLGLT TPSAQAQQQL IRDAYRQAGI
PESDMWQTAM VECHGTGTAV GDTIEACTVG TVFGEKGMLI GSVKPNLGHS EAASAITSIV
KAVLSLETRT IIPNIKFENP SISILFDTSG LKVPTEPLPW PEDRAERIGV NSFGIGGTNV
HIIIDSSASV AYPTAVRGPG NVDTPPPSPP LRRESATLLL FSASNEESLK KAVRGYQNII
QANPLKLEAL AHTLTHRRSH LAYRTFAVVA GESGNMAPEF PPAPTFRPKS ESKDITFVFT
GQGAQWARMG SHLMKASKEF LQDIREMDAA LKCLPREHQP AWEISRELMR ADAGSRLGEA
EFAQPVCTAL QVALVRHLAR YGVSPKAVVG HSSGEIAAAY AAGTLTIKEA IIVAYYRGYM
AKKLEKRGAM AAVGLGRDQV TRFLTTGVVI ACENSNSSVT LSGDLDVLRA VCEDIHAAKP
DALVRILKVD KAYHSHHMKS IGAEYQALLK SHLNPKSPKI SFYSSVSPHT PLRGADFGPE
YWQRNLESPV LFRQAVTRLL QTSSTSLLLE VGPHSALAGP LKQICSENSI SPPYVAAQKR
GLNSAASFLA AVGELHCRGA AVDFPVMDGV RPLTDLPRYP WNLSKTYWPD SRITNLWQFP
EYPPHELLGH RALETGNAEP SWRCCLSLDK VPWIKDHQVG SDIVFPAAGY VAMAGEAVRQ
LTEHTGFTIR EMRIMNALVI SPGKAVELLT SFRRQRLTHN DVSEWWELTV QSCSSADTWT
THCTCLIKGG NDLEVRNLPG LHKASFLRVT EPSRWYKQMS RVGYNYGPLF QCMQMVRSSV
TSPAVEVEIS DCRVGGSAAQ SYAIHPTTID HVFQSLVVAN SSGEPRQLDK LYLPTYVEEI
TINAKTETRG CLIQTLKTGR DGYCQGESIG FVPGNPTGQP LVHMKGLQFS PIDIVDSTKH
SPDTSKVTHL VWKPDVDLAA STDLIQPTSP DDFSKFHGLL EDLFILCGLA TLREVGVAGV
LSEQTQPHLR KHYQWLESHI VRSSRAWPAL TTVEIHNKIR DISLQLEKTP ASAVATLISR
CYTHAQSLFS SDIGPLELFL QDNALHELYD WMNTLFTYKP LLQLLSHKRG RHLRILEIGA
GTGGLTARIL KCLTECFDDG KALGKYVFTD VSSGFFPAAK ARFETIPEGF LDYRVLDISH
DPADQGFGGE QYDLIVASNV LHATPDLTKT LQHVRTLLKP EGRLLMHELC CDTKWINFIM
GYLSGWWLGE SDSRIDEPYI SPDRWEERLA LAGFEKPDVF YDAEQQHRLN ATIVARPAHS
TSKMPSLSGE ITILCEEESH PVVVDLRNHL QKQGHSVTCT TLSAGNIQPC APVVSAVDLC
RGDGYFHDMT QGKLDDFKRL LQKLQSNNLG LLWLTRPCQV DPQNPTFAPV LGVARTCRIE
MGFPFSTLEV DGDGTDALTA VSRVLQKTLL RHGSSKLTHD EDAEFSYSSG RIFVPRCKWL
PISRALQDTT SPSPSKMLHI SRTGALQSLC WIPRRLSDQI PSDQVQIKVH AAGLNFKDVV
TAMGLIDPSS PKGLGCEASG VVTATGSLVT NLRIGDRVMV FAPQAACFST DIQAPAQLCV
RIPDELGFAD AATMPCVFVT VLRALLDKAG LQAGQTLLVH SAAGGVGIAA MQVARWIGAT
VYATVGSEEK VDFISKTWNI PREHIFSSRD SRFVEGIKTA TGGRGVDVVL NSLAGELLHA
SWECVAPHGT FIELGKRDTL AGGRLAMEAF DGNRSFIGVE MANLAAQDPG IIARLLQRCI
QLYKQGHITP VRPSRMFSCR EAEDAFRHIY KGTHVGKVVI DMQKAAVETL DVVPRQLPAP
AFCNEATYLL VGGMGGLGAS IARWMACHGA RSFIFLSRSA GNSAVDQDLL AELRGRGCEV
EAVSCDITNE TELHAAASRL PLWKRIRGVM NLAMVLSDAA LPNLTLSQWE TATSPKIRGT
WNLHRVLPSD LDFFVLFGST SGIHGYPGQA NYAAANTFLD AFVQYRRRHG LPCSVLDLGG
VEDVGYVSRT REVEDAMKKA GSKLLSESNM LRGLQLAMAQ SLSGDAGLES AIAGLGFGGQ
VLIGLECSIP LDDVNNRVVW KQDPRMVLYP EDSDTPTRDG KQSGASGLSE FLARLQSKPE
EVDTPSSIAY LAQEIALRVC GFLMKEVDET GVDTSVSPSA LGVDSLMTIE IRNWWKHSLG
GDISVLQLTS AQSFDQLGHL AAKQLKKKMD LAANI
//