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Database: UniProt
Entry: H2AN94_KAZAF
LinkDB: H2AN94_KAZAF
Original site: H2AN94_KAZAF 
ID   H2AN94_KAZAF            Unreviewed;       850 AA.
AC   H2AN94;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   05-JUL-2017, entry version 26.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=KAFR0A04090 {ECO:0000313|EMBL:CCF55844.1};
GN   ORFNames=KAFR_0A04090 {ECO:0000313|EMBL:CCF55844.1};
OS   Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 /
OS   CECT 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces
OS   africanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF55844.1, ECO:0000313|Proteomes:UP000005220};
RN   [1] {ECO:0000313|EMBL:CCF55844.1, ECO:0000313|Proteomes:UP000005220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC   NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S.,
RA   Byrne K.P., Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type
RT   switching accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE650821; CCF55844.1; -; Genomic_DNA.
DR   RefSeq; XP_003954979.1; XM_003954930.1.
DR   EnsemblFungi; CCF55844; CCF55844; KAFR_0A04090.
DR   GeneID; 13886443; -.
DR   KEGG; kaf:KAFR_0A04090; -.
DR   InParanoid; H2AN94; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000005220; Chromosome 1.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:EnsemblFungi.
DR   GO; GO:0016049; P:cell growth; IEA:EnsemblFungi.
DR   GO; GO:0043623; P:cellular protein complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0006797; P:polyphosphate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005220};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    415    439       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    459    477       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    537    558       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    570    592       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    629    649       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    747    770       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    776    799       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   850 AA;  97741 MW;  07DA8B68D52D3716 CRC64;
     MNAEKDEAIF RSAEMALLQF YIPQEMSREA VYTIGKLGIV QFRDLNSKVR SFQRSFIDEI
     KKLDNVQRQY RFLYSLLEKH NIPLFEEDYE EREATRYNPP VTTSVIDDHV QNATFLEDRL
     LQMEDATAQI ELQKADLEQY RFVLQAGDQF FASEADSNVS AADPQALHRR DSFDFELQVA
     NISYVTGVIP RDKINTLEQI LWRVLRGNLF FKHVELPTPV CDTKTKGHVD KNAFIIFSHG
     DLIIKRIKKI AESLDAKLYS IDKNAELRSE HLNGVNKTLD DLYQVLRTTV ATLESELYAV
     SKELNKWFQE IYKEKLVYET LNKFNYDSNR KTLIAEGWVP KDEISFLQNH LNDMTRRLGI
     DVPSIIQTLE TNKTAPTYHK TNKFTQGFQA IVDCYGIAQY REVNAGLPTI VTFPFMFAIM
     FGDLGHGFIM FLAALTLVLN EKKLNRMKRG EIFDMAFTGR YIVLLMGLFS MYTGLLYNDV
     FSKSMTLFES GWKWPKTWNK GETIFAEQVG VYSFGLDWAW HGTENALLFS NSYKMKLSIL
     MGFLHMSYSY MFSLVNHLHF KSMIDIIGNF IPGLIFLQSI FGYLSICIVY KWSKDWIRDE
     KPAPSLLNML INMFLSPGVI DDKLYPHQAT VQVVLLFLAL ICIPWLLLVK PLHFKYFHNK
     GGKIELLMEE NDAEGSTASV SHFEMETEHS PIEIEEIYGP SGAENDMDDD DTKEDEENFG
     DIVIHQVIHT IEFCLNCVSH TASYLRLWAL SLAHAQLSSV LWSMTIQIAF SFTGVGGVLI
     TVVLFAMWFV LTCAVLVLME GTSAMLHSLR LHWVESMSKF FVGDGIPYEP FILEYADMET
     TVITTGPRTQ
//
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