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Database: UniProt
Entry: H2ATB3_KAZAF
LinkDB: H2ATB3_KAZAF
Original site: H2ATB3_KAZAF 
ID   H2ATB3_KAZAF            Unreviewed;       412 AA.
AC   H2ATB3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   13-SEP-2023, entry version 46.
DE   RecName: Full=Lipoyl-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=KAFR0C06210 {ECO:0000313|EMBL:CCF57613.1};
GN   ORFNames=KAFR_0C06210 {ECO:0000313|EMBL:CCF57613.1};
OS   Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS   1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF57613.1, ECO:0000313|Proteomes:UP000005220};
RN   [1] {ECO:0000313|EMBL:CCF57613.1, ECO:0000313|Proteomes:UP000005220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC   NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007317}.
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DR   EMBL; HE650823; CCF57613.1; -; Genomic_DNA.
DR   RefSeq; XP_003956748.1; XM_003956699.1.
DR   AlphaFoldDB; H2ATB3; -.
DR   STRING; 1071382.H2ATB3; -.
DR   GeneID; 13885531; -.
DR   KEGG; kaf:KAFR_0C06210; -.
DR   eggNOG; KOG0557; Eukaryota.
DR   HOGENOM; CLU_035825_2_1_1; -.
DR   InParanoid; H2ATB3; -.
DR   OrthoDB; 52212at2759; -.
DR   Proteomes; UP000005220; Chromosome 3.
DR   GO; GO:0045254; C:pyruvate dehydrogenase complex; IEA:InterPro.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:InterPro.
DR   CDD; cd06849; lipoyl_domain; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 4.10.320.10; E3-binding domain; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR045257; E2/Pdx1.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR23151; DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR23151:SF82; PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR   SUPFAM; SSF51230; Single hybrid motif; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Lipoyl {ECO:0000256|ARBA:ARBA00022823};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          32..108
FT                   /note="Lipoyl-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50968"
FT   DOMAIN          169..210
FT                   /note="Peripheral subunit-binding (PSBD)"
FT                   /evidence="ECO:0000259|PROSITE:PS51826"
FT   REGION          125..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   412 AA;  46225 MW;  1A26FCBAA09ABEC5 CRC64;
     MLGINLVRTA ARLVLKRNSA RCLHNSAKVW DIQPFLMPAM SPTMEKGGIV SWKVEVGNTF
     SAGDVLLEVE TDKAQIDVEA QDDGKLAKIL RKDGSKDISV GETIAFIAEP NDDLSTLEIP
     EIAQDKREKA HASSGKKDEL QAKSSPQATP TKGAKRSAVK LHTANPNQTL LPSVSLLLAE
     NNLSKEDAFN NIEATGLNGR LLKGDVLAYL GRIDNENLLG ITEYIRNSES LDLSNIKVKP
     RQAMETQEIS KEKVEETKKE AAIKKAPLIL NEEIILTVPS EVNELKLSKS LRSFIDEAYH
     YTHRASLENE QSNYFDAIFD ELTTPNLRAP RFKYSYDIIP LNTNSNNMMG EEDDIFDILS
     SRKRRASVES RRNNEKTNDY LLNLRVAVSN RFLDSEKKAS RFIEYIKQVE IF
//
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