ID H2AWD2_KAZAF Unreviewed; 827 AA.
AC H2AWD2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=SPX domain-containing protein {ECO:0000259|PROSITE:PS51382};
GN Name=KAFR0F00850 {ECO:0000313|EMBL:CCF58682.1};
GN ORFNames=KAFR_0F00850 {ECO:0000313|EMBL:CCF58682.1};
OS Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF58682.1, ECO:0000313|Proteomes:UP000005220};
RN [1] {ECO:0000313|EMBL:CCF58682.1, ECO:0000313|Proteomes:UP000005220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; HE650826; CCF58682.1; -; Genomic_DNA.
DR RefSeq; XP_003957817.1; XM_003957768.1.
DR AlphaFoldDB; H2AWD2; -.
DR STRING; 1071382.H2AWD2; -.
DR GeneID; 13884150; -.
DR KEGG; kaf:KAFR_0F00850; -.
DR eggNOG; KOG1281; Eukaryota.
DR HOGENOM; CLU_005170_8_0_1; -.
DR InParanoid; H2AWD2; -.
DR OrthoDB; 5485124at2759; -.
DR Proteomes; UP000005220; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR CDD; cd01115; SLC13_permease; 1.
DR CDD; cd14478; SPX_PHO87_PHO90_like; 1.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10283:SF92; LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91; 1.
DR PANTHER; PTHR10283; SOLUTE CARRIER FAMILY 13 MEMBER; 1.
DR Pfam; PF03600; CitMHS; 1.
DR Pfam; PF03105; SPX; 2.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 363..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..221
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 258..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 92093 MW; 500614D9AB0E8567 CRC64;
MKFSHSLQFN SVPEWSSKYI AYSNLKKTIY NLQKEKLYNN ISSASSVSNV VDTEQQPLLL
DTSTDPYIKR FLEQLNSEVK KIDKFFISQK TGLIANYNEL NDDIRDFEVS LLTAPVFKRR
RSTRRLSSVS SNESMLSQNL PLSIDSGPDD EIEGINEDFN YYTRMNPLLQ QSVILKKRIV
VLFTQLSELK DYIELNKTGF RKICKKFDKS LNTSIKDPFM EKLCQGSNTF KPETLAKITE
YIDECIVTYA KLSNQDSTGN LGLNKTNTSD DNGSSQGTEP QDFVPYDFEN AKKELSTHLR
EHVVWERNTV WKDMMNLERK SQNAKASTSE KIEPLDSSLN LTLSDFLSLP PAKIINLVVN
SNSFIKFAAI TAIFILLLCY YSPFNDVLQQ NCFAILIYAS LLWATETIPL FVTSLFIPLL
IVIFPTLKDP VSNIPLNSIQ SSQYILSSMW TSVIMLLLGG FTLAAALSKY NIAKVLSTHI
LSSAGTNPKV ILLTIMFVAS FVSMWVSNVA APVLCYSIIQ PLLRTLPRHN TFSKSLILGI
ALASNVGGMA SPIASPQNIF AFGIMNSPPS WVEWFIITTP VCIICNFIIW VMLLVSFPID
YKNTKILKLH RITDPFTVTQ WFVSIVCVVT ILLWCLSNKL SSQLGEMGII SIIPILLLFG
TGLLSSDDFN NFMWNIVVLA MGGSTLGKAV SNSGLLATIA HLIKEEIQDE SLIYIIITFG
LCVLVMATFI SHTVSAMIVV PLMGEIGANL PGDHSKLLIM ISTLLCSCAM GLPTSGFPNV
TAISMIDEAG DRYLSVMHVI SRGVPVSIAC YFIVVTVGFG MMKLLGY
//
