ID H2B1K2_KAZAF Unreviewed; 238 AA.
AC H2B1K2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN Name=KAFR0K01480 {ECO:0000313|EMBL:CCF60502.1};
GN ORFNames=KAFR_0K01480 {ECO:0000313|EMBL:CCF60502.1};
OS Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF60502.1, ECO:0000313|Proteomes:UP000005220};
RN [1] {ECO:0000313|EMBL:CCF60502.1, ECO:0000313|Proteomes:UP000005220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- SIMILARITY: Belongs to the peptidase C56 family. HSP31-like subfamily.
CC {ECO:0000256|ARBA:ARBA00038493}.
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DR EMBL; HE650831; CCF60502.1; -; Genomic_DNA.
DR RefSeq; XP_003959637.1; XM_003959588.1.
DR AlphaFoldDB; H2B1K2; -.
DR STRING; 1071382.H2B1K2; -.
DR GeneID; 13886691; -.
DR KEGG; kaf:KAFR_0K01480; -.
DR eggNOG; ENOG502RZ3Y; Eukaryota.
DR HOGENOM; CLU_070319_1_0_1; -.
DR InParanoid; H2B1K2; -.
DR OrthoDB; 4342at2759; -.
DR Proteomes; UP000005220; Chromosome 11.
DR CDD; cd03147; GATase1_Ydr533c_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
SQ SEQUENCE 238 AA; 25652 MW; 5B7B8FCD82CF4595 CRC64;
MVANKRVLIA LTSYHGPLYA DGSKTGVFLV EALHPFNTYK ARGYEVDFVS ETGSFGWDAH
SLTEDFLNGQ DRKDYENKDS EFNKALANVK KPSEVNAADY SIFFASAGHG TLFDYPTAKG
LQSIAADIYE QGGVLSAVCH GPAIFDGLND KKTGKNVLTG KVITGFTDVG EAIMGVDTVM
KEKNLLSVED IAKKYNVKYL APIGPWDDFS ITDGRIVTGV NPASASSVAT RSMDAAEK
//
