ID H2CBS5_9LEPT Unreviewed; 629 AA.
AC H2CBS5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN ORFNames=Lepil_3876 {ECO:0000313|EMBL:EHQ08529.1};
OS Leptonema illini DSM 21528.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptonema.
OX NCBI_TaxID=929563 {ECO:0000313|EMBL:EHQ08529.1, ECO:0000313|Proteomes:UP000005737};
RN [1] {ECO:0000313|EMBL:EHQ08529.1, ECO:0000313|Proteomes:UP000005737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21528 {ECO:0000313|EMBL:EHQ08529.1,
RC ECO:0000313|Proteomes:UP000005737};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B.,
RA Kyrpides N., Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E.-M.,
RA Klenk H.-P., Eisen J.A.;
RT "The Improved High-Quality Draft genome of Leptonema illini DSM 21528.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH597773; EHQ08529.1; -; Genomic_DNA.
DR RefSeq; WP_002775285.1; NZ_JH597773.1.
DR AlphaFoldDB; H2CBS5; -.
DR STRING; 183.GCA_002009735_02248; -.
DR HOGENOM; CLU_000022_3_6_12; -.
DR Proteomes; UP000005737; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EHQ08529.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005737}.
FT DOMAIN 29..82
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 86..476
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 528..606
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 629 AA; 70612 MW; 5B54704F057A9311 CRC64;
MSTIDTLMQQ DQRLQPTESL KQNALIQDYE ALYLHSITQP DSFWGGIASD LVWDQKWDKV
MEFNAPHHKW FLNGKLNITK NVLDRHVAGP NRNRVAIIWS SEQGEEVLVT YDRLLRRVCQ
VANALKAMGV KKGDRVIIYM PLTLQGIYSM LACARIGAIH SVVYAGMGVQ ALRNRIEDSH
AKVIICSDIT YRNGKIVPLK GIVDEAVEDL EFVEHIVVHR RQEPQVEFGS LKEVDFNEVM
EAQPQWCEPE IMDSEDPLFI LYTSGTTGRP KGVVHVHGGY MVGTYYLSRA FYDIKDGDIF
WSTSDIGWIV GHSYIVYGPL LNGATIVARE GAINYPDPGV VWKVVERHGV NVMFTAPTAI
RMFMRFGEEF VNKYDIRSLR LIASAGEPLN PEAQLWAQKN ILKDHGYIVD NWWQTEIASP
VLGTLASMEA KVGKVGRPMP GAIVDVVSPD GEKVAPNKGG LLIIRRPLPY MMRTIWNDDD
RYKEYWSEFP GCYSAGDVAF YDEDGYFCVL GRADDVMNVA GHRIGTAEVE GAFVSHPAVA
EAAVIGLPDE VKGERIKGFV VLRPGHEPTE NLRLTLRDHV RRELGPIATP SEVDFRTNLP
KTRSGKIVRR LLKAQEMGQD AGDLSTLED
//
