ID H2CDH4_9LEPT Unreviewed; 585 AA.
AC H2CDH4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=Lepil_1824 {ECO:0000313|EMBL:EHQ06507.1};
OS Leptonema illini DSM 21528.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptonema.
OX NCBI_TaxID=929563 {ECO:0000313|EMBL:EHQ06507.1, ECO:0000313|Proteomes:UP000005737};
RN [1] {ECO:0000313|EMBL:EHQ06507.1, ECO:0000313|Proteomes:UP000005737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21528 {ECO:0000313|EMBL:EHQ06507.1,
RC ECO:0000313|Proteomes:UP000005737};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B.,
RA Kyrpides N., Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E.-M.,
RA Klenk H.-P., Eisen J.A.;
RT "The Improved High-Quality Draft genome of Leptonema illini DSM 21528.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; JH597773; EHQ06507.1; -; Genomic_DNA.
DR RefSeq; WP_002772089.1; NZ_JH597773.1.
DR AlphaFoldDB; H2CDH4; -.
DR STRING; 183.GCA_002009735_02859; -.
DR HOGENOM; CLU_027270_1_0_12; -.
DR Proteomes; UP000005737; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11070:SF3; ATP-DEPENDENT HELICASE_DEOXYRIBONUCLEASE SUBUNIT B; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005737}.
FT DOMAIN 365..559
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13361"
SQ SEQUENCE 585 AA; 67213 MW; 93CE7C2B754D9659 CRC64;
MTRQSPAEQA SIEALKQLRS CIDNNQCFRL EAGAGAGKTY SLIETIKYLI EQRASEFLLN
EQQIACITYT NVAKDEIKDR TDHHPVIFAD TIHAFCWSIL QNYQIKLREL LPSLGERWEE
RIKEAGGIAE QIVKYDLGYP RINNREISLH HDDVVFLMAR ILSYPKFQKL VKSKFPIILI
DEYQDTDVHL AESVVTNLVD NESGVIIGLF GDHWQKIYGS AACGLISSKA GKIVEIGKKA
NFRSDKNIVA CLNRMRPELP QAESNPQSQG AVRIFHSNLW VGTRRGGGHW TGDLPTANAK
EHIEKVKELM VADGWDMSPT KTKILFLTNN LIATEQNFKN LADCFPYPDD YLKKGDKYIQ
FFIDIIEPTA SAFERREYGE LFQIGNKNHP SLQSQRDKKI WTDNLNRLME LRNTGSIGEV
LDLLLESKTP RASAKVEESE RKFNLLSDGA ADSHSEEEKR FLEKIRSIRT VKYREVINLH
EYIDEKTPFS TKHGVKGAEF DNVLVVFGRG WNQYNWNQML EWMSDGYPAD KRETFERNRN
LFYVSCSRAK HNLTLLFTQE LSQKALSMIQ KIFETRNVIG DPFEQ
//
