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Database: UniProt
Entry: H2CIL8_9LEPT
LinkDB: H2CIL8_9LEPT
Original site: H2CIL8_9LEPT 
ID   H2CIL8_9LEPT            Unreviewed;       585 AA.
AC   H2CIL8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   07-JUN-2017, entry version 18.
DE   SubName: Full=Thiamine pyrophosphate central domain-containing protein {ECO:0000313|EMBL:EHQ07034.1};
GN   ORFNames=Lepil_2358 {ECO:0000313|EMBL:EHQ07034.1};
OS   Leptonema illini DSM 21528.
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptonema.
OX   NCBI_TaxID=929563 {ECO:0000313|EMBL:EHQ07034.1, ECO:0000313|Proteomes:UP000005737};
RN   [1] {ECO:0000313|EMBL:EHQ07034.1, ECO:0000313|Proteomes:UP000005737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21528 {ECO:0000313|EMBL:EHQ07034.1,
RC   ECO:0000313|Proteomes:UP000005737};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N.,
RA   Held B., Kyrpides N., Mavromatis K., Ivanova N., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S.,
RA   Brambilla E.-M., Klenk H.-P., Eisen J.A.;
RT   "The Improved High-Quality Draft genome of Leptonema illini DSM
RT   21528.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; JH597773; EHQ07034.1; -; Genomic_DNA.
DR   RefSeq; WP_002772756.1; NZ_JH597773.1.
DR   EnsemblBacteria; EHQ07034; EHQ07034; Lepil_2358.
DR   OrthoDB; POG091H02KO; -.
DR   Proteomes; UP000005737; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1220; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005737};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005737};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN       18    176       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      199    332       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      397    544       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   585 AA;  63446 MW;  DA71D1C999E0DD1D CRC64;
     MSTTKIKGGN LTGAYLARYA LEQLPVKHVF GIPGVHNTEL YDEINKSEKI EPILVTHEGG
     GAFMADGISR TSDEIGTLLI VPAAGTTHAM SGIGEAFLDG IPMLVISGGI RSDIPVSYQL
     HELDLPRLLS SITKFAKRVE RHDQIVPTIF EAYRHAVSGE PGPVFVEIPV NIQLFKGEVA
     ELPVYQDLPA QPAPSDADLD RAVDLLLKSK QPGLFLGWGA KGAREAAIQI ADLLGAPVST
     TLQGLTVFPA DHPMHTGMGF GAHSVPAAEN AFADVDCMLA VGTRFAEIPT GSFGAKVPEN
     LIHVDINSQV FHRNHRAKVA LHGDSAIVLN ALLERLKKAS VSSTDRHEKK AAQIARDKAA
     YYKEWEAHRN ERVNPYLFFR ELKSKADKDM LMVVDDGNHT FLSAELFPVT HPVGFISPTD
     FNCMGYSVPA AIGAKLASPS RQVVSIVGDG AFLMTGLEII TASSHGLGVT YFVFYDGELS
     QISQGQEIPY NRKTCTVLGN IRLKGIADAT GAAYVELNSN EEIGSKIEEA LRIAESGRPV
     IVDVKIDYSK RTRFTKGVVG TVLKRFPIGD KFRFIGRALW RKLTG
//
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