ID H2CS92_TRYCR Unreviewed; 160 AA.
AC H2CS92;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Pyruvate dehydrogenase E1 component alpha subunit {ECO:0000313|EMBL:AET14074.1};
DE EC=1.2.4.1 {ECO:0000313|EMBL:AET14074.1};
DE Flags: Fragment;
GN Name=PDH {ECO:0000313|EMBL:AET14074.1};
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693 {ECO:0000313|EMBL:AET14074.1};
RN [1] {ECO:0000313|EMBL:AET14074.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CL Brener {ECO:0000313|EMBL:AET14067.1}, EPP38
RC {ECO:0000313|EMBL:AET14075.1}, EPV20-1 {ECO:0000313|EMBL:AET14076.1},
RC P63cl1 {ECO:0000313|EMBL:AET14068.1}, TEP6cl5
RC {ECO:0000313|EMBL:AET14070.1}, TEP7 {ECO:0000313|EMBL:AET14071.1},
RC TEP80 {ECO:0000313|EMBL:AET14072.1}, TEV66
RC {ECO:0000313|EMBL:AET14073.1}, TEV67 {ECO:0000313|EMBL:AET14074.1},
RC and TolV23 {ECO:0000313|EMBL:AET14069.1};
RX PubMed=22210092; DOI=10.1016/j.meegid.2011.12.008;
RA Lauthier J.J., Tomasini N., Barnabe C., Rumi M.M., D'Amato A.M.,
RA Ragone P.G., Yeo M., Lewis M.D., Llewellyn M.S., Basombrio M.A.,
RA Miles M.A., Tibayrenc M., Diosque P.;
RT "Candidate targets for Multilocus Sequence Typing of Trypanosoma cruzi:
RT Validation using parasite stocks from the Chaco Region and a set of
RT reference strains.";
RL Infect. Genet. Evol. 0:0-0(2011).
RN [2] {ECO:0000313|EMBL:AET14074.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CL Brener {ECO:0000313|EMBL:AET14067.1}, EPP38
RC {ECO:0000313|EMBL:AET14075.1}, EPV20-1 {ECO:0000313|EMBL:AET14076.1},
RC P63cl1 {ECO:0000313|EMBL:AET14068.1}, TEP6cl5
RC {ECO:0000313|EMBL:AET14070.1}, TEP7 {ECO:0000313|EMBL:AET14071.1},
RC TEP80 {ECO:0000313|EMBL:AET14072.1}, TEV66
RC {ECO:0000313|EMBL:AET14073.1}, TEV67 {ECO:0000313|EMBL:AET14074.1},
RC and TolV23 {ECO:0000313|EMBL:AET14069.1};
RA Lauthier J., Tomasini N., Barnabe C., Monje Rumi M., Alberti D'Amato A.M.,
RA Ragone P.G., Yeo M., Lewis M.D., Llewellyn M.S., Basombrio M.A., Miles M.,
RA Tibayrenc M., Diosque P.;
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AIB07490.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tulahuencl2 {ECO:0000313|EMBL:AIB07490.1};
RX PubMed=25167160;
RA Diosque P., Tomasini N., Lauthier J.J., Messenger L.A., Monje Rumi M.M.,
RA Ragone P.G., Alberti-D'Amato A.M., Perez Brandan C., Barnabe C.,
RA Tibayrenc M., Lewis M.D., Llewellyn M.S., Miles M.A., Yeo M.;
RT "Optimized Multilocus Sequence Typing (MLST) Scheme for Trypanosoma
RT cruzi.";
RL PLoS Negl. Trop. Dis. 8:E3117-E3117(2014).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; JN129688; AET14067.1; -; Genomic_DNA.
DR EMBL; JN129689; AET14068.1; -; Genomic_DNA.
DR EMBL; JN129690; AET14069.1; -; Genomic_DNA.
DR EMBL; JN129691; AET14070.1; -; Genomic_DNA.
DR EMBL; JN129692; AET14071.1; -; Genomic_DNA.
DR EMBL; JN129693; AET14072.1; -; Genomic_DNA.
DR EMBL; JN129694; AET14073.1; -; Genomic_DNA.
DR EMBL; JN129695; AET14074.1; -; Genomic_DNA.
DR EMBL; JN129696; AET14075.1; -; Genomic_DNA.
DR EMBL; JN129697; AET14076.1; -; Genomic_DNA.
DR EMBL; KF889519; AIB07490.1; -; Genomic_DNA.
DR VEuPathDB; TriTrypDB:C3747_2g671; -.
DR VEuPathDB; TriTrypDB:ECC02_007562; -.
DR VEuPathDB; TriTrypDB:Tc_MARK_4984; -.
DR VEuPathDB; TriTrypDB:TcCL_ESM04030; -.
DR VEuPathDB; TriTrypDB:TcCLB.507831.70; -.
DR GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AET14074.1}; Pyruvate {ECO:0000313|EMBL:AET14074.1}.
FT DOMAIN 1..155
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
FT REGION 135..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AET14074.1"
FT NON_TER 160
FT /evidence="ECO:0000313|EMBL:AET14074.1"
SQ SEQUENCE 160 AA; 18489 MW; ABF9C7427117F9D7 CRC64;
GQVFEAMNIA AIHRIPVIFC CENNQFGMGT SKERAAYQPE MYRRGDYIPG LQVDGMDVLA
VQEGTRWAKE WCLSGKGPIV LEFDSYRYVG HSMSDPDSQY RKKSDIQDVR KTRDCIHKMK
DFMLXEGIMT DEEMKKLEKD VKKEVDQQLX PAEKQXPTPR
//
