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Database: UniProt
Entry: H2D328_9NEOP
LinkDB: H2D328_9NEOP
Original site: H2D328_9NEOP 
ID   H2D328_9NEOP            Unreviewed;       221 AA.
AC   H2D328;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic {ECO:0000256|ARBA:ARBA00040860};
DE   AltName: Full=Cytosolic NADP-isocitrate dehydrogenase {ECO:0000256|ARBA:ARBA00041229};
DE   AltName: Full=IDPc {ECO:0000256|ARBA:ARBA00041648};
DE   Flags: Fragment;
GN   Name=IDH {ECO:0000313|EMBL:AEY63189.1};
OS   Forsebia perlaeta.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Erebidae; Erebinae; Forsebia.
OX   NCBI_TaxID=1126705 {ECO:0000313|EMBL:AEY63189.1};
RN   [1] {ECO:0000313|EMBL:AEY63189.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zahiri R., Holloway J.D., Kitching I.J., Lafontaine J.D., Mutanen M.,
RA   Wahlberg N.;
RT   "Molecular phylogenetics of Erebidae (Lepidoptera, Noctuoidea).";
RL   Syst. Entomol. 37:102-124(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH;
CC         Xref=Rhea:RHEA:19629, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.42;
CC         Evidence={ECO:0000256|ARBA:ARBA00036496};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19630;
CC         Evidence={ECO:0000256|ARBA:ARBA00036496};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; JN401753; AEY63189.1; -; Genomic_DNA.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR004790; Isocitrate_DH_NADP.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11822:SF21; ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC; 1.
DR   PANTHER; PTHR11822; NADP-SPECIFIC ISOCITRATE DEHYDROGENASE; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Glyoxylate bypass {ECO:0000256|ARBA:ARBA00022435};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT   DOMAIN          1..221
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEY63189.1"
FT   NON_TER         221
FT                   /evidence="ECO:0000313|EMBL:AEY63189.1"
SQ   SEQUENCE   221 AA;  25296 MW;  9B02C3CE3A8779FE CRC64;
     HVYDMGMENR DKTDDQVTID CAEAIKKYNV GIKCATITPD ENRVEEFKLK KMWKSPNGTI
     RNILGGTVFR EAIICKNIPR LVTGWEKPII IGRHAHADQY KATDFVVPGA GKLELVFTPA
     NGEPIRHVVN EYKGAGVALG MFNTDASIID FAHSSFKYAL GRKYPLYLST KNTILKKYHG
     RFQDIFQEIY YREYKSTFXA AGIWYXHWLD DDMVAYSMKS E
//
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