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Database: UniProt
Entry: H2DEP8_9BACT
LinkDB: H2DEP8_9BACT
Original site: H2DEP8_9BACT 
ID   H2DEP8_9BACT            Unreviewed;       263 AA.
AC   H2DEP8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Adenyltransferase {ECO:0000313|EMBL:AEX31566.1};
GN   Name=aadA12 {ECO:0000313|EMBL:AEX31566.1};
OS   uncultured bacterium.
OC   Bacteria; environmental samples.
OX   NCBI_TaxID=77133 {ECO:0000313|EMBL:AEX31566.1};
RN   [1] {ECO:0000313|EMBL:AEX31566.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang X.-X., Ma L.-P.;
RT   "Occurrence, abundance and diversity of ARG related mobile genetic elements
RT   in sewage treatment plants.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC         Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC         Evidence={ECO:0000256|ARBA:ARBA00001672};
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DR   EMBL; JN588535; AEX31566.1; -; Genomic_DNA.
DR   RefSeq; WP_071846190.1; NG_052144.1.
DR   AlphaFoldDB; H2DEP8; -.
DR   GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR024172; AadA/Aad9.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Transferase {ECO:0000313|EMBL:AEX31566.1}.
FT   DOMAIN          28..76
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          153..254
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
SQ   SEQUENCE   263 AA;  29452 MW;  A2800C76A6C93049 CRC64;
     MREAVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLDE
     TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG
     IFEPATIDID LAILLIKARE HSVALVGPAA EEFFDPVPEQ DLFEALRETL KLWNSQPDWA
     GDERNVVLTL SRIWYSAITG KIAPKDVAAD WAIKRLPAQY QPVLLEAKQA YLGQKEDHLA
     SRADHLEEFI RFVKGEIIKS VGK
//
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