ID H2DQ62_9VIRU Unreviewed; 1883 AA.
AC H2DQ62;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=ORF1 protein {ECO:0000256|ARBA:ARBA00042213};
OS Apple chlorotic leaf spot virus.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Tymovirales; Betaflexiviridae; Trivirinae; Trichovirus.
OX NCBI_TaxID=12175 {ECO:0000313|EMBL:AEY80040.1};
RN [1] {ECO:0000313|EMBL:AEY80040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Z3 {ECO:0000313|EMBL:AEY80040.1};
RA Niu F.Q., Pan S., Li S.F.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEY80040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Z3 {ECO:0000313|EMBL:AEY80040.1};
RX PubMed=22278708; DOI=10.1007/s00705-011-1195-5;
RA Niu F., Pan S., Wu Z., Jiang D., Li S.;
RT "Complete nucleotide sequences of the genomes of two isolates of apple
RT chlorotic leaf spot virus from peach (Prunus persica) in China.";
RL Arch. Virol. 157:783-786(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; JN634761; AEY80040.1; -; Genomic_RNA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23245; Betaflexiviridae_RdRp; 1.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR002588; Alphavirus-like_MT_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001788; RNA-dep_RNA_pol_alsuvir.
DR InterPro; IPR008744; RNA-dir_pol_ACLSV.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR Pfam; PF05413; Peptidase_C34; 1.
DR Pfam; PF00978; RdRP_2; 1.
DR Pfam; PF01443; Viral_helicase1; 1.
DR Pfam; PF01660; Vmethyltransf; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 63..232
FT /note="Alphavirus-like MT"
FT /evidence="ECO:0000259|PROSITE:PS51743"
FT DOMAIN 746..834
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT DOMAIN 1025..1335
FT /note="(+)RNA virus helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51657"
FT DOMAIN 1632..1739
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 618..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1883 AA; 216170 MW; AB2C255502AA48A5 CRC64;
MAFSYRTPQE ELLSRLPQSQ QEVISGFQYE RIQKEEEKKV ENFSFYLPEK TREWFTKSGV
YLSPFAYVNH SHPGCKTLEN HLLFNVVASY ISKYPYVACL SIKSNKMSKM ERLGSNSVKT
YDILNRLVTA KDKARYGPLA KPERSPCPKK TNVFIHDEIH YWSRDQLETF LQIYKPKNLW
ATLVFPPEIL AGYKSSVLPF LYQFEIHGKD LVYMPDGVRS ESYTQPLENG YLLSSSSILI
KDRTTGVEVR YQVSLTYSLG SHHLFHIYPT ENLMKEEVRR FGPYDLFDVG SLFVKPVRVP
IQDFPLSVFK KIFIYMSSLK KPDVQSAVAK LRQLSDADIS IESVFMVQEF ASRIEKDGIE
RWSCSFWGCM KDWFFDKLPY REVLEKIGLA DDFTRRLMKI KPLAFDIYTT DRPLTVRMVI
DQIWGERQSS HDDMPNIVFY GRREWIEHGV VPKVKKGLAK LIPGREFDTN DYPREIYSDL
LSSTSLWRSY DDNLKHRNAS PLIVLKSSKA YSEAAEFNSH CLSLCATPCG EKVAKTPFEL
EHEKRKKELS TECLNFHIKK MKVKNLLELE EKLGEHKKKI PRRGKKIKEQ RRSRMIPVHL
LTPIDDVEVK ELKVKEKERT KPHIDKGADE AKRNAEPSDV GPKVENVMPD AQCVLKSPVG
LKLSNLVGKT QLCSAGLIKT VGNDYLALAE QVESMPLVQL KGKKAAYFCL DFPMVYFHDK
VSYPTFEATG EIKQVMIKAK EKWGINFNSA LVQVYNDGCR LPLHSDNEEC YDDDGILTIN
IRGDAKFHTT CHDEITDLKQ GNEILMPAGY QKKNRHAVEV NSEGRTSVTL RVHKRDFSFE
SKLRFIKGKF DCLFVSIAEI IHKKPEEVMM FIPHIMDRCI SNRGCSLDDA KAICEKYEIK
IECEGDCGLV ECGTSGLSIG RMLLRGNHFS VASVRRSSMD SLANSSKEIK SSGVLDHVTF
NFHKRLKLVE PDLTMVDVKV DSPRAGKLLK SLMDGMTGIV SHNSTHEGWR MIKGINSTSE
MRSFMSMARG QGEETKGDLF DKVQELNFMK VKIYGIFGFA GSGKSHAIQN LIQSEFKGSQ
GVMVICPRRF LAKDWNEKGV DEKDIKTFES ALKSDVKGKR LFILDEVSLL PKGFTDLLML
KMHMEGILKK STIVCIGDPL QAGYFCPKDD NYLSREGEIK RLFKEGVNYK WYSYRINKFV
AKKLAIETMN DFIGIDEQSS IYKDMPSAHH FMEKKGNHIE VILVASMVEK ELYSNYGNVM
TFGESQGLTF NCGVIVLSEE AKLCSDAHIM VAITRFRRGF CFALGSKGSK EDYMRSMKSG
LLQRMCFGVG ASKEFILGSS SVNLILSEKD ITKGAGVDEM DREARLEGDV WLKSMIYLGK
RYHIIEPLGQ VIKLTDGAIK CHIPVCSSQT LGPELDHIQA REFREFKGKN GWSNQFREEA
GPNWKFPYRV NQAMSHEAVY PRHKMDDDLT FLAAIRKRLR FDNVANNYAK FKAAESRGKY
LAKVFLKHVP IKCGRDQRLL DQCRQEFEET KLSKSAATIG AHSQRSDSDW PLDKIFLFMK
SQLCTKFEKR FTEAKAGQTL ACFPHKILVE FSPWCRYTEK VLTANLPDNY YIHQRKNFCE
LEDFAKRFSN GSTCVESDYT AFDVSQDHTI LAFEVELLKH FGWDDRILQS YIKMKCTLGC
RLGGFAIMRF TGEFSTFLFN TLANMVFTFC RYEVPDGTPI CFAGDDTCAL RNLREIDTHE
FILSKLSLKA KVNRTKVPMF CGWRLCCDGL IKEPCLIYER LQVAIENGRL MDVIDSYFLE
FSFAYKLGER LYSHLEIEQL NYHQVLTRFF IRNKHLLRGD SRHSISELEW LSDEDGDDGK
GSQVEDRRRG YSNCWGEKLQ NLF
//
