ID H2DXR8_9POXV Unreviewed; 493 AA.
AC H2DXR8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=DNA helicase {ECO:0000313|EMBL:AEY74605.1};
GN ORFNames=VAC_DPP19_149 {ECO:0000313|EMBL:AEY74605.1};
OS Vaccinia virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10245 {ECO:0000313|EMBL:AEY74605.1, ECO:0000313|Proteomes:UP000181371};
RN [1] {ECO:0000313|EMBL:AEY74605.1, ECO:0000313|Proteomes:UP000181371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dryvax {ECO:0000313|EMBL:AEY74605.1};
RX PubMed=21976639; DOI=10.1128/JVI.05779-11;
RA Qin L., Upton C., Hazes B., Evans D.H.;
RT "Genomic analysis of the vaccinia virus strain variants found in Dryvax
RT vaccine.";
RL J. Virol. 85:13049-13060(2011).
CC -!- FUNCTION: DNA helicase which seems to act as a postreplicative
CC transcription termination factor. Involved in ATP-dependent release of
CC nascent RNA. Forms a stable complex with single-stranded DNA, and to a
CC lesser extent RNA. {ECO:0000256|ARBA:ARBA00037581}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the helicase family. Poxviruses subfamily.
CC {ECO:0000256|ARBA:ARBA00038498}.
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DR EMBL; JN654984; AEY74605.1; -; Genomic_DNA.
DR Proteomes; UP000181371; Genome.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18785; SF2_C; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:AEY74605.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000313|EMBL:AEY74605.1};
KW Hydrolase {ECO:0000313|EMBL:AEY74605.1};
KW Late protein {ECO:0000256|ARBA:ARBA00022921};
KW Nucleotide-binding {ECO:0000313|EMBL:AEY74605.1};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT DOMAIN 100..256
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 493 AA; 56690 MW; 7245631E86D70354 CRC64;
MSLLKMEYNL YAELKKMTCG QPLSLFNEDG DFVEVEPGSS FKFLIPKGFY ASPSVKTSLV
FETLTTTDNK ITSINPTNAP KLYPLQRKVV SEVVSNMRKM IESKRPLYIT LHLACGFGKT
ITTCYLMATH GRKTVICVPN KMLIHQWKTQ VEAVGLEHKI SIDGVSSLLK ELKTQSPDVL
IVVSRHLTND AFCKYINKHY DLFILDESHT YNLMNNTAVT RFLAYYPPMM CYFLTATPRP
SNRIYCNSII NIAKLSDLKK TIYAVDSFFE PYSTDNIRHM IKRLDGPSNK YHIYTEKLLS
VDEPRNQLIL NTLVEEFKSG TINRILVITK LREHMVLFYK RLLDLFGPEV VFIGDAQNRR
TPDMVKSIKE LNRFIFVSTL FYSGTGLDIP SLDSLFICSA VINNMQIEQL LGRVCRETEL
LDRTVYVFPS TSIKEIKYMI GNFMQRIISL SVDKLGFKQK SYRKHQESDP TSACTTSSRE
ERVLNRIFNS QNR
//
