ID H2EP72_HELAM Unreviewed; 528 AA.
AC H2EP72;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Cryptochrome-1 {ECO:0000256|ARBA:ARBA00021159};
OS Helicoverpa armigera (Cotton bollworm) (Heliothis armigera).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Helicoverpa.
OX NCBI_TaxID=29058 {ECO:0000313|EMBL:AEX49898.1};
RN [1] {ECO:0000313|EMBL:AEX49898.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu P.J., Wu K.M., Cheng P.;
RT "Cloning, sequence analysis and expression of cryptochrome 1 gene in cotton
RT bollworm, Helicpverpa armigera.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGA11657.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu P., Wu K.;
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AGA11657.1}
RP NUCLEOTIDE SEQUENCE.
RA Xiao H., Cheng P.;
RT "Up-regulated cryptochrome genes expression in cotton bollworm (Helicoverpa
RT armigera) during migrating over the Bohai Sea.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR602081-1};
CC Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR602081-1};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC {ECO:0000256|ARBA:ARBA00005862}.
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DR EMBL; JN997418; AEX49898.1; -; mRNA.
DR EMBL; JQ713131; AGA11657.1; -; mRNA.
DR EMBL; JQ713134; AGA11660.1; -; mRNA.
DR EMBL; JQ713135; AGA11661.1; -; mRNA.
DR AlphaFoldDB; H2EP72; -.
DR SMR; H2EP72; -.
DR EnsemblMetazoa; XM_049843844.1; XP_049699801.1; LOC110372048.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.80; -; 1.
DR Gene3D; 1.10.579.10; DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11455; CRYPTOCHROME; 1.
DR PANTHER; PTHR11455:SF17; CRYPTOCHROME-1; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR Pfam; PF03441; FAD_binding_7; 1.
DR PRINTS; PR00147; DNAPHOTLYASE.
DR SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 2: Evidence at transcript level;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR602081-1};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|PIRSR:PIRSR602081-
KW 1}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 3..133
FT /note="Photolyase/cryptochrome alpha/beta"
FT /evidence="ECO:0000259|PROSITE:PS51645"
FT BINDING 242
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 300..307
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 399..401
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT SITE 331
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 386
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 409
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
SQ SEQUENCE 528 AA; 60644 MW; 4AFAAD1978257ED2 CRC64;
MLGGSVLWFR HGLRLHDNPS LHSALEEKGF PFFPIFIFDG ETAGTKLVGY NRMRYLLEAL
DDLDSQFKKF GGRLIMLKGK PNVVFRRLWE EFGIRKLCFE QDCEPVWRAR DDSVKSACKE
IGVVCREHVS HTLWEPETVI KANGGIPPLT YQMFLHTVAT IGDPPRPVPN IDFTGVKFGS
LPECFYQEFT VYDKTPKPED LGVFLENEDI RMIRWVGGET TALKQMQQRL SVEYETFLRG
SYLPTHGNPD LLGPPISLSP ALRFGCLSVR SFYWAVQDLF RQVHQGRLTT NSASHFITGQ
LIWREYFYTM SVNNPNYGQM AGNPICLDIP WKNPEGDELQ RWVEGRTGFP FVDAAMRQLR
TEGWLHHAAR NTVASFLTRG TLWLSWEHGL NHFLKYLLDA DWSVCAGNWM WVSSSAFEAL
LDSGECACPV RLGQRLDPSG EYVRRYVPEL ARMPVEYIYE PWKAPIDVQE RATCVIGKDY
PAPVVNHLVA AQRNKNAMKE LRHMLQKAPP HCCPSSEDEI RQFMWLNE
//
