ID H2J5S0_MARPK Unreviewed; 252 AA.
AC H2J5S0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Multisubunit Na+/H+ antiporter, MnhB subunit {ECO:0000313|EMBL:AEX85056.1};
GN OrderedLocusNames=Marpi_0617 {ECO:0000313|EMBL:AEX85056.1};
OS Marinitoga piezophila (strain DSM 14283 / JCM 11233 / KA3).
OC Bacteria; Thermotogota; Thermotogae; Petrotogales; Petrotogaceae;
OC Marinitoga.
OX NCBI_TaxID=443254 {ECO:0000313|EMBL:AEX85056.1, ECO:0000313|Proteomes:UP000007161};
RN [1] {ECO:0000313|EMBL:AEX85056.1, ECO:0000313|Proteomes:UP000007161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14283 / JCM 11233 / KA3
RC {ECO:0000313|Proteomes:UP000007161};
RX PubMed=23045491; DOI=10.1128/JB.01430-12;
RA Lucas S., Han J., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N.C., Ivanova N., Pagani I., Vannier P.,
RA Oger P., Bartlett D.H., Noll K.M., Woyke T., Jebbar M.;
RT "Complete Genome Sequence of the Thermophilic, Piezophilic, Heterotrophic
RT Bacterium Marinitoga piezophila KA3.";
RL J. Bacteriol. 194:5974-5975(2012).
RN [2] {ECO:0000313|Proteomes:UP000007161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14283 / JCM 11233 / KA3
RC {ECO:0000313|Proteomes:UP000007161};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Jebbar M.,
RA Vannier P., Oger P., Cario A., Bartlett D., Noll K.M., Woyke T.;
RT "Complete sequence of chromosome of Marinitoga piezophila KA3.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B
CC family. {ECO:0000256|ARBA:ARBA00009425}.
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DR EMBL; CP003257; AEX85056.1; -; Genomic_DNA.
DR AlphaFoldDB; H2J5S0; -.
DR STRING; 443254.Marpi_0617; -.
DR KEGG; mpz:Marpi_0617; -.
DR eggNOG; COG2111; Bacteria.
DR HOGENOM; CLU_069132_3_0_0; -.
DR Proteomes; UP000007161; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR PANTHER; PTHR33932; NA(+)/H(+) ANTIPORTER SUBUNIT B; 1.
DR PANTHER; PTHR33932:SF4; NA(+)_H(+) ANTIPORTER SUBUNIT B1; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007161};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..107
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 122..238
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 252 AA; 27152 MW; C26B31EE8EBAAB3F CRC64;
MMKRVIAGLI VIVLGIFIFT SLYAPKSSEG KFFPEFGKAN LSERVSDKFV KKNVTGDNGE
VVYKETKDPE SGSANMVTSI VVNYRSFDTL GEVTVLFVSA LGVGLLLSGK SRMKFKTPPN
FILKSAVRVI AGVILITGVY IFIHGHLTPG GGFPGGSMIA SAVLLFYLSD DEFKTKMKSF
KLLEGTAGSL YLIFGLLGLA YGGYFLYNFL PTGTVGELFS AGIVPIIYIF VGLKVGSELS
NLISDFLSEE GK
//
