ID H2J7X0_MARPK Unreviewed; 792 AA.
AC H2J7X0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN OrderedLocusNames=Marpi_1049 {ECO:0000313|EMBL:AEX85461.1};
OS Marinitoga piezophila (strain DSM 14283 / JCM 11233 / KA3).
OC Bacteria; Thermotogota; Thermotogae; Petrotogales; Petrotogaceae;
OC Marinitoga.
OX NCBI_TaxID=443254 {ECO:0000313|EMBL:AEX85461.1, ECO:0000313|Proteomes:UP000007161};
RN [1] {ECO:0000313|EMBL:AEX85461.1, ECO:0000313|Proteomes:UP000007161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14283 / JCM 11233 / KA3
RC {ECO:0000313|Proteomes:UP000007161};
RX PubMed=23045491; DOI=10.1128/JB.01430-12;
RA Lucas S., Han J., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N.C., Ivanova N., Pagani I., Vannier P.,
RA Oger P., Bartlett D.H., Noll K.M., Woyke T., Jebbar M.;
RT "Complete Genome Sequence of the Thermophilic, Piezophilic, Heterotrophic
RT Bacterium Marinitoga piezophila KA3.";
RL J. Bacteriol. 194:5974-5975(2012).
RN [2] {ECO:0000313|Proteomes:UP000007161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14283 / JCM 11233 / KA3
RC {ECO:0000313|Proteomes:UP000007161};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Jebbar M.,
RA Vannier P., Oger P., Cario A., Bartlett D., Noll K.M., Woyke T.;
RT "Complete sequence of chromosome of Marinitoga piezophila KA3.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; CP003257; AEX85461.1; -; Genomic_DNA.
DR RefSeq; WP_014296533.1; NC_016751.1.
DR AlphaFoldDB; H2J7X0; -.
DR STRING; 443254.Marpi_1049; -.
DR KEGG; mpz:Marpi_1049; -.
DR eggNOG; COG1067; Bacteria.
DR HOGENOM; CLU_014785_0_1_0; -.
DR Proteomes; UP000007161; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046:SF46; ARCHAEAL LON PROTEASE; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000007161};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 551..747
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 642
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 685
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 792 AA; 91422 MW; C7D2AC4A95138E21 CRC64;
MLLKYDDFKI KMPQLNFENT ENIQSITEYI GQKRAYDSMV LGIEIEEKTH NIFITGPVNT
GRRTFARNVL TKYSLNKKTP NDYIYVYNFK DPMKPKAISL KSGEAIIFKK ILKETIEISF
EALKKGIEGE DFSEKRTQLE DEYLKARKSV WDDLKKEVEK LGFKLQFTTN GAMTIPVYDG
KEVTDEEYDK LPEDVRNSFE EKTPILRQLM EKAMIKITEY DKKYREQLRN LEKYWALFTI
SGIFEDLINE YSTNSDVIEF LNEIKNDIAE NFQDILSSDE SITNYYKKKY SVNVIIDNSS
IKGAPVIEAN DPAYSSLIGK IEYFSHMGML KTDFTMIKPG LLHKANGGYL ILDAEKVMRS
PYVWEALKNA LMNNEIKIEN LEGKMGLSVV HTLEPDPIPL NVKVILVGEE WMYEVLYQYD
PDFKKLFNVK VAFDTEIELN KENAEYFAGF VKNIVKQHEL KDFTKGAVEE LLKYSCRINE
RNDRFSAKFG VLKNIILEAN YISDRYSDTI PYVDKNAVIK AIQKHENMFS LYRDKIFDSI
KDGQLIIDTE GEKIGQINGL TVVDFDTYSF GVPVKITGNV SSAKQVGVID IHRDADLSGK
IHRKSTFIIE NYFYSKYNLD EHMVFSGSIS FEQTYSMLEG DSASLAEILV LLSAISKIPL
KQYIAVTGSI DQHGNIQPVG GIIEKVEGFY YTCKLKGLKG NEGVIIPHQN IKNLVLNNEI
EEDIKKGKFR IYAVKNVDEA IEIMTEYTAG KLNENGEFEE NSFNWHIIKR IKELRKIEDE
KSHKKRFWLW GK
//
