ID H2KP45_CLOSI Unreviewed; 1012 AA.
AC H2KP45;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Transient receptor potential-gamma protein {ECO:0000313|EMBL:GAA35086.2};
DE Flags: Fragment;
GN ORFNames=CLF_101323 {ECO:0000313|EMBL:GAA35086.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA35086.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA35086.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA35086.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DF142875; GAA35086.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KP45; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF54; TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:GAA35086.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 432..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 732..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 285..347
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 30..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1012
FT /evidence="ECO:0000313|EMBL:GAA35086.2"
SQ SEQUENCE 1012 AA; 115945 MW; 709FB340B1B0788E CRC64;
MSPSKRQQKY TLPEVVDVVL FRHQALKKRP KYRARNASPE QIPNTSTGMT IHEKAGPRTE
KRRSTRRSSS VGQTTDVRTL NFREVGEFEK DEVRKEVNDV IAEVESDLAG RTDKKSGRRA
GVVDLGGLEL PLEEGELSRA ERCFLHAAES GDLGTLKELL DRTELLNFNP NCTDALGRDA
LRIVIENEHL ELLDLLVHSP LIDLKDSLLH AINEDNTAAV EVILQAQTER ACKKNLKGLL
GRIQSSSFTP DITPIILAAH RDNYMILKLL LDRGDRIPKP HDLRCSCHNC VQARRTDGLQ
HSKLRINAFR ALTSPSFIIL TSNDPILTAF EMSYELRQLG ELENEFRTDY EELSEKCETF
ATELLGETRS SVELSVILNH DTDDSEEEYL QLPRLKLAIK YEQKKFVAHP HCQQLLASMW
YDGLPGFRQK PMLAQLTTMG TLCAMFPVLA TCYMLAPRSK PGGLMKKPFI KFLCHSSAYL
SFLGLLLLAA VRIESLLTNT MDERMNDRAP WPSLSEAALV VYVLGFLWQE IKKVYTWGFR
AYISDMWHLL DFIMISMYIS TIAMRTVAII RVQLYNEDRF VNRGQWDSFD PILISECLFA
GANIVSTLKL VYVFTVSPQL GPLQISLGRM LYDIFKFFCV YVLVIVAFAF GLNQLFWFYA
NNRARNCKNV HFTLEEGQKD VYDYCITRGT HFTNLFEIAQ SLYWSSYGLI DLTSFNLEYP
HAFTEFVGKL TFGVYSYIAF IVLLNMLIAM MNSSYEQIVQ QVDVEWKFAR SKLWISYFVE
GCTVPVPFNL VPTPKSFMYM MQFIKNSIRK CCQKNDQQSE WDIMKKYVKM IKEREARYMV
VMRELTKRYI MKKLRAAEFE PVGADDLNEI KGDISAFRFE LLDILKANGM NIPMIYRKTG
KLRKNRDGLQ TSDYEDISSF KETLLEKAKG VESKKSATGL FRATVDMARA RATMDSLHHG
GPVENPAFVS DEPDFKQKGQ TVECVSELEP FPTTTRDVAV VRRLRSIKDS EK
//
