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Database: UniProt
Entry: H2KPE8_CLOSI
LinkDB: H2KPE8_CLOSI
Original site: H2KPE8_CLOSI 
ID   H2KPE8_CLOSI            Unreviewed;       418 AA.
AC   H2KPE8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-NOV-2023, entry version 41.
DE   SubName: Full=Gastricsin {ECO:0000313|EMBL:GAA43397.2};
GN   ORFNames=CLF_101839 {ECO:0000313|EMBL:GAA43397.2};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA43397.2, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA43397.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA43397.2};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
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DR   EMBL; DF142900; GAA43397.2; -; Genomic_DNA.
DR   AlphaFoldDB; H2KPE8; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.60.40.1960; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          45..350
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
SQ   SEQUENCE   418 AA;  48019 MW;  A50A18F1E2E8B943 CRC64;
     MGQIVYAFSA IDDNFWVSES LSLRRRSEFG INVYEFSFLF YLGLAYGFIQ IGEQQFRVMF
     DTGGFSRWVP SSRSAANLFP NRVKYDEKSP TRTSLEKRYV ASYSGKRYEG NVVMDNVLFP
     FVEMICCSTN VDANVKHDGI FGMRKPPRDR KRLEIFKVNL IDHFLAMGTV QQAVFTFRFC
     GQPGVREFSW FVNGNLIFGG VREDFHHLPI VYLPTYQSKQ WTVYIDSILY GDVVLCMPCR
     ANLDTGTPGT RVPVKPIQKL LQNSVLEAYD AGVLHVPFQS LPYLLPITIN MRSHAFILHP
     EQLVRQVGNV YVFAMEGMQD ASENKWLIGI SFLRHFHTIF DQQNNRVGFA AGWRTIFRLC
     YSLPFVACST AGIPQNDHHT KVGLVVFIHP RTTDILNRFY YPEQECQYFG GDVFACTD
//
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