ID H2KQF1_CLOSI Unreviewed; 514 AA.
AC H2KQF1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Metabotropic glutamate receptor 3 {ECO:0000313|EMBL:GAA38071.2};
GN ORFNames=CLF_103791 {ECO:0000313|EMBL:GAA38071.2}, CSKR_107524
GN {ECO:0000313|EMBL:KAG5447478.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA38071.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA38071.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA38071.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAG5447478.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Cs-k2 {ECO:0000313|EMBL:KAG5447478.1};
RX PubMed=29454982;
RA Wang D., Korhonen P.K., Gasser R.B., Young N.D.;
RT "Improved genomic resources and new bioinformatic workflow for the
RT carcinogenic parasite Clonorchis sinensis: Biotechnological implications.";
RL Biotechnol. Adv. 36:894-904(2018).
RN [4] {ECO:0000313|EMBL:KAG5447478.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Cs-k2 {ECO:0000313|EMBL:KAG5447478.1};
RX PubMed=33677057;
RA Young N.D., Stroehlein A.J., Kinkar L., Wang T., Sohn W.M., Chang B.C.H.,
RA Kaur P., Weisz D., Dudchenko O., Aiden E.L., Korhonen P.K., Gasser R.B.;
RT "High-quality reference genome for Clonorchis sinensis.";
RL Genomics 0:0-0(2021).
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DR EMBL; DF142997; GAA38071.2; -; Genomic_DNA.
DR EMBL; NIRI02000042; KAG5447478.1; -; Genomic_DNA.
DR AlphaFoldDB; H2KQF1; -.
DR STRING; 79923.H2KQF1; -.
DR InParanoid; H2KQF1; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR Proteomes; UP000286415; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF158; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:GAA38071.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..514
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035652661"
FT DOMAIN 65..448
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
FT REGION 116..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 57328 MW; D8C6B4AA9BD44701 CRC64;
MPVHGRSSRL VVLSLCLYLC FGVDTRTTLF VDYPGDIMLG GLFPVHTTGT TNCNVINPER
GIQRVEAMLF TLDEINNDTK LLPGLRLGAI IRDTCSASQF ALEQALHFVL SSTDKCPADR
GEGSGEKRGL NKDTPTTRGV VGSSYSSVSI LVANLFRLFS IPQISYASTS AVLSDKRAFP
LFARTVPSDV VQARAMATLV HDHNWTYVST VRSAGDYGDS GMDAFWKEAD KLGVCIAARE
VIRINSGTED LDAIVRVLRY DFAKARVVVL FTGMDHTKLL LDAVQRAGLV DHFVWIASDG
WGRENLPVAN NSRVANGALT IEIQAKPVTE FTEHYLNLGY DNPRNPWFRK YWEELFDCTF
DTDAMASKQH GRRLLQTFAY RSVKRRSATE SRTKPCSRDR NQRLRDRLSS GFQQEAKVQF
VYNAVYAFAH GLHKLQEQLC PGNPYHPSWD KYMCIERLLN FSGTEFYETM ISTSFTAVYG
NIGVESGASS TYNDEFIDKN DKELSGTSAS AILP
//
