ID H2KR29_CLOSI Unreviewed; 757 AA.
AC H2KR29;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Rho GTPase-activating protein 26 {ECO:0000313|EMBL:GAA29402.2};
GN ORFNames=CLF_105290 {ECO:0000313|EMBL:GAA29402.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA29402.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA29402.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA29402.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DF143096; GAA29402.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KR29; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF1; RHO GTPASE-ACTIVATING PROTEIN GRAF; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 245..348
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 334..527
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 34..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 85042 MW; 980167C73613C6F1 CRC64;
MVAHLEETPE DDSELRDALG SFAASLTAYC TANNASPPLS ARSQEDSDKR GSAEVAETDD
EVTIKTAFIE FAKIIHAVED ARSMMLTPFK PMILNEIQEL RSEWLLGPKT DPKDFLKETT
TFCQKLEKYL SVKQKERTPE LDEQMLQDRQ RFITRAFEHV TNIHEAEELK KSKFVQTISL
FMQMMANFYH QAFEHFQDSQ RQLSNINQAA QRSAANFRQI SDETKELKEK LLKTPWEQVQ
SNDSAAFREG YLFIQVKKPV TTLWIKHFCT YSRDLRSLQV IPYTQGRSSD LIQESYSIKT
CTRRSSETID RRFCFDVEVD NRSTPLTLQA QSQADLLEWL RIMDGQEPLY ADRFGLVQDN
KVNPDTRLET QGIYRISGVR LKVTALVRQA MSPPGLSKSV LSTYETHMLT SAVKHFVRNL
DEPLVTFALH HEFIAAIKRN PSERVQEVAR LINLLPRANQ RALQLLMSHL AKVSAHSRVN
SMTPSNLGIV FAPSVMRSPE ETVAAIMNTK FASSVVELMI EHHATLFPST DGELLDTLPM
PVKEPVPIEP VYSTPVLDSK APSPREARLV DLGLYRPAKA DNATSILATV QHQPVVGDTP
NASKAAGDVL GSNEDLPPRP PVPPRLGLTS PRRRQSEQNK RVLPSRPSEP SNRIIITHPQ
PINDDVDRPN IGQLVSSDNN SRGEPDKMED LPPRVPGKIQ RPHGQSAVGF PNVLSLTSAF
NHQPSIPPQP PVRKRPDQAA CLVNQSVDNG KDPITVS
//
