ID H2KS78_CLOSI Unreviewed; 1011 AA.
AC H2KS78;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 2 {ECO:0000313|EMBL:GAA30706.2};
GN ORFNames=CLF_108417 {ECO:0000313|EMBL:GAA30706.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA30706.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA30706.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA30706.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DF143319; GAA30706.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KS78; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10217:SF548; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 7-LIKE; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 341..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 674..791
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 212..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1011 AA; 112824 MW; 8073D0775CD877C7 CRC64;
MPIKRGHVAP QNTFIDTLIQ KFDSQRRKFL IANAVLPQTP IIFCNDDLCT MCGYSRAEIL
QRSAALEFLY GPLTSSKAVG ELKQALTDTE ERVILAILYN KAGFHFVCQI AVAPVRNAEC
QVRLYILTFR GMSDFEDADV VKSKSDRGKL SVLASQFHRI VGLTRILTSI GHRATHSPAH
HTTVIPEEIN QEQFVHSSME LASTVSLARR HSSADHHFGQ SSDSAHLGAP EAASSHLNLS
TVSQTSSMLL DGGETTKKSH RCFPTRTNSG SSQGLRVGSA VAHGTGGIVI TTDSGLMSHR
NVSDKVAEML SLGPDVHPEH KLHSPRIHPF TLKHYGPVKA VWDWLILGLV IYTAIFTPYA
AAFHLLEENK TTRKSGEWST LRAIDFFVDI MFIIDIFINF RTTYVNKNDE LISDPGRIAV
HYFKGWLLID VVAAIPFDLI QIGAQTDDMV KLIGLLKTAR LLRLVRVVRK LDRYSEYGAA
VLLLLMATFV LIAHWLACIW YFVGHIQRQK HYIWTGWLDT LAAQIQQPYT NRSTMGPTIQ
AKYITALYFT FSSLTSVGFG NVSPNTNPEK IFSICVMLVG SLMYAGIFGH VSAIIQRLYS
GTARYHIQML RVKEFIRFHQ IPNPLKRRLE EFFQHAWSYT NGIDMNFVLR SFPECLQADI
CLHLNRHLFE TSLPFKGASQ GCLRSLALKM KTTHVQPGDT LVHKGDVLCF ICFIARGSIE
VVMGSDIVAV LCQGDVFGEN PFGQDLMGQS KFCVRALTYC DLHKIQHDDL FEILEMYPEF
AKRFRQKLEI TLDLQNAPVP GDVCPMHWDG ALKKLSICHH MDTGKGDQPY ETDFPAPLTI
KGPLSSSAPY LSMLEQEAID LDRPLLREND RLLSAARITN NTQNKEHPLS PVPFSTSTEL
RKLGSPPPSR HDGVASASPV HETRPPRYPP STVLPRTELD LLPDSNDYDT VVPLGVGSID
LGSLMVGLTT RLLSIEQQLV DLEQKFDANL SEVLQLVQTI PTSNLPSTMA A
//
