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Database: UniProt
Entry: H2KSG1_CLOSI
LinkDB: H2KSG1_CLOSI
Original site: H2KSG1_CLOSI 
ID   H2KSG1_CLOSI            Unreviewed;      1037 AA.
AC   H2KSG1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=Ras homolog gene family member T1 {ECO:0000313|EMBL:GAA30666.2};
GN   ORFNames=CLF_109228 {ECO:0000313|EMBL:GAA30666.2};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA30666.2, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA30666.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA30666.2};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC       pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
CC       Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004200}; Single-
CC       pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004200}.
CC   -!- SIMILARITY: Belongs to the mitochondrial Rho GTPase family.
CC       {ECO:0000256|ARBA:ARBA00007981}.
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DR   EMBL; DF143389; GAA30666.2; -; Genomic_DNA.
DR   AlphaFoldDB; H2KSG1; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR013566; EF_hand_assoc_1.
DR   InterPro; IPR013567; EF_hand_assoc_2.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR020860; MIRO_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   PANTHER; PTHR24072:SF73; MITOCHONDRIAL RHO GTPASE; 1.
DR   PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR   Pfam; PF13202; EF-hand_5; 2.
DR   Pfam; PF08355; EF_assoc_1; 1.
DR   Pfam; PF08356; EF_assoc_2; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS51423; MIRO; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          254..439
FT                   /note="Miro"
FT                   /evidence="ECO:0000259|PROSITE:PS51423"
FT   DOMAIN          575..610
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          925..963
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        925..959
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1037 AA;  116439 MW;  BE20137F3531F100 CRC64;
     MGRGFPGARN PEPQTWIRNF CRADFSGMRI FLNQVKLGPA SVEDLYRTIV QKVHEADAMY
     VPKKPARSRT SRKLPKRIRR LLEKRSQLFL KKLTTGDTED ELAFRKMRNR CKSEIRQWNI
     RKQATILDLA RKNRNVLFKY MRHRRFTPCL NKAWPTGFSP LTQQTHGGDT HGVLPSIMMM
     REDTSVAMFD FRHGFCRSYP QHVYTDTCCR RNLSVRLNFI RLQSFQPNRK RLCHTGRLVA
     LSTLFELGLD DQRPIAEVFP KKDTAQVGKT TLILSLVSEE FSPKCPNGQV SGPKRSDLLV
     DWVPAQAEEI TIPADVTPER VPTQIVDYSS RTQSHEQLCA EIRRADVICL VHALDDEKSL
     ERISSYWLPL IRHNGANPDC RSPIVLVGNK LDLLNESKLS VALPIMSEFS EVETCIECSA
     KTLLNLSETF WFAQKAVLYP TAPLYDAERK ELTPACIRAL TRVFRICDTD NDGYLSDREL
     EAFQSRCFSV PLTTQSLQDV KQLVRQSCPG GVTLNGITQK GFLFLHLIFV QKGRHETTWT
     VLRQFGYDNQ IRLSNEFLFP RFSVPSGCTT ELSTLGTQFL HMLFNKYDLD RDGCLSPSEL
     SEMLAIFPED QLSHVSELTD SVTTNSTGWI TCQGFLAYWA LTAYLEPTRV LEYFAHLGFT
     YFAAGSFWST VNSHRQQQQH PKDPYDSTPS TPLLIGALPL RDRLIGQNPA NSAVRSDAGG
     SSVPMSRSTR DALLRSLVIT TEKRLDTIRR STQRTVFYCR VYGARKVGKT CLLQGLLGRH
     LRGTGGLAIG GLSGRSSGWA AATGIQVYGQ QRTLIMHEIG AAGGEQMTAG EALSADVACL
     VYDVSDPDSF RYVANLFLNY YRGTRVPCLF VESKSDQPRV VQNYQVDPVE LTAKYNLNPP
     EPFSSMNMEQ CLNVLASSST RNVASSLSDS APRSRSATNL FPNPVPNRRA GSLEPSSSTA
     GGEIHLLKDS SHKLSPGIGL SLLSLDKESA QLNPPLDARG RRHSKPDLAY RPSTEFSARD
     TNFLPVYVTL CTLANYP
//
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