ID H2KSG1_CLOSI Unreviewed; 1037 AA.
AC H2KSG1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Ras homolog gene family member T1 {ECO:0000313|EMBL:GAA30666.2};
GN ORFNames=CLF_109228 {ECO:0000313|EMBL:GAA30666.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA30666.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA30666.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA30666.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004200}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004200}.
CC -!- SIMILARITY: Belongs to the mitochondrial Rho GTPase family.
CC {ECO:0000256|ARBA:ARBA00007981}.
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DR EMBL; DF143389; GAA30666.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KSG1; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR013566; EF_hand_assoc_1.
DR InterPro; IPR013567; EF_hand_assoc_2.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR020860; MIRO_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072:SF73; MITOCHONDRIAL RHO GTPASE; 1.
DR PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR Pfam; PF13202; EF-hand_5; 2.
DR Pfam; PF08355; EF_assoc_1; 1.
DR Pfam; PF08356; EF_assoc_2; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51423; MIRO; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 254..439
FT /note="Miro"
FT /evidence="ECO:0000259|PROSITE:PS51423"
FT DOMAIN 575..610
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 925..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1037 AA; 116439 MW; BE20137F3531F100 CRC64;
MGRGFPGARN PEPQTWIRNF CRADFSGMRI FLNQVKLGPA SVEDLYRTIV QKVHEADAMY
VPKKPARSRT SRKLPKRIRR LLEKRSQLFL KKLTTGDTED ELAFRKMRNR CKSEIRQWNI
RKQATILDLA RKNRNVLFKY MRHRRFTPCL NKAWPTGFSP LTQQTHGGDT HGVLPSIMMM
REDTSVAMFD FRHGFCRSYP QHVYTDTCCR RNLSVRLNFI RLQSFQPNRK RLCHTGRLVA
LSTLFELGLD DQRPIAEVFP KKDTAQVGKT TLILSLVSEE FSPKCPNGQV SGPKRSDLLV
DWVPAQAEEI TIPADVTPER VPTQIVDYSS RTQSHEQLCA EIRRADVICL VHALDDEKSL
ERISSYWLPL IRHNGANPDC RSPIVLVGNK LDLLNESKLS VALPIMSEFS EVETCIECSA
KTLLNLSETF WFAQKAVLYP TAPLYDAERK ELTPACIRAL TRVFRICDTD NDGYLSDREL
EAFQSRCFSV PLTTQSLQDV KQLVRQSCPG GVTLNGITQK GFLFLHLIFV QKGRHETTWT
VLRQFGYDNQ IRLSNEFLFP RFSVPSGCTT ELSTLGTQFL HMLFNKYDLD RDGCLSPSEL
SEMLAIFPED QLSHVSELTD SVTTNSTGWI TCQGFLAYWA LTAYLEPTRV LEYFAHLGFT
YFAAGSFWST VNSHRQQQQH PKDPYDSTPS TPLLIGALPL RDRLIGQNPA NSAVRSDAGG
SSVPMSRSTR DALLRSLVIT TEKRLDTIRR STQRTVFYCR VYGARKVGKT CLLQGLLGRH
LRGTGGLAIG GLSGRSSGWA AATGIQVYGQ QRTLIMHEIG AAGGEQMTAG EALSADVACL
VYDVSDPDSF RYVANLFLNY YRGTRVPCLF VESKSDQPRV VQNYQVDPVE LTAKYNLNPP
EPFSSMNMEQ CLNVLASSST RNVASSLSDS APRSRSATNL FPNPVPNRRA GSLEPSSSTA
GGEIHLLKDS SHKLSPGIGL SLLSLDKESA QLNPPLDARG RRHSKPDLAY RPSTEFSARD
TNFLPVYVTL CTLANYP
//