UniProt: H2KTP2

Database: UniProt
Entry: H2KTP2_CLOSI

LinkDB:  H2KTP2_CLOSI 
Original site:  H2KTP2_CLOSI

All links

Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (3)   
   InterPro (2)   
   Pfam (1)   
Literature (1)   
   PubMed (1)   
All databases (9)   

Download RDF

ID   H2KTP2_CLOSI            Unreviewed;       551 AA.
AC   H2KTP2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=tRNA (uracil-O(2)-)-methyltransferase {ECO:0000256|RuleBase:RU368004};
DE            EC=2.1.1.211 {ECO:0000256|RuleBase:RU368004};
GN   ORFNames=CLF_105409 {ECO:0000313|EMBL:GAA29832.2};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA29832.2, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA29832.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA29832.2};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
CC   -!- FUNCTION: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-
CC       methyltransferase. {ECO:0000256|RuleBase:RU368004}.
CC   -!- FUNCTION: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA
CC       (uracil-O(2)-)-methyltransferase. {ECO:0000256|ARBA:ARBA00002778}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-
CC         methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43100, Rhea:RHEA-COMP:10339, Rhea:RHEA-COMP:10340,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; EC=2.1.1.211;
CC         Evidence={ECO:0000256|ARBA:ARBA00000660,
CC         ECO:0000256|RuleBase:RU368004};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU368004}.
CC   -!- SIMILARITY: Belongs to the TRM44 family.
CC       {ECO:0000256|ARBA:ARBA00009056, ECO:0000256|RuleBase:RU368004}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DF143923; GAA29832.2; -; Genomic_DNA.
DR   AlphaFoldDB; H2KTP2; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0141101; F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030488; P:tRNA methylation; IEA:UniProtKB-UniRule.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR011671; tRNA_uracil_MeTrfase.
DR   PANTHER; PTHR21210:SF0; TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR21210; UNCHARACTERIZED; 1.
DR   Pfam; PF07757; AdoMet_MTase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU368004};
KW   Methyltransferase {ECO:0000256|RuleBase:RU368004,
KW   ECO:0000313|EMBL:GAA29832.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368004};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU368004};
KW   tRNA processing {ECO:0000256|RuleBase:RU368004}.
SQ   SEQUENCE   551 AA;  63098 MW;  FCFB9DDA56084B96 CRC64;
     MSTLSNFYST VNIWIHKPHV VHPKIFGAKV KNKDNNLLER LVIPKEKSHF KPFSERIERS
     GTEVFFTSEQ ITYVIRLQDS LISTAVLHTS GLGLLTVEWI SNEFQRKLNE WLSQDLKPVI
     PTLCLIDVAE YQCIYNKLKN TYARGIVQYW CERTDPLKFT YEDLGIAAYL ICLWKGTEKK
     SIHFVDVGCG NGLLVSILIN EGFNGVGVDI RKRKIWSSYP DSVQNRLLVQ QCSGFPDATW
     LIGNHSDELT PWIPVLAARS GPDCKVFLLP CCPFSLFGKY NNFTHYPNEQ ESTSASASVE
     FQSRYRVYLK YLHGLFRLCG FEPESDVLRI PSTKRVCLVG RTFSPSSANY PSRMSSVEAA
     VYKEKLSVSA TTCFVPRSYH EPVLNCTHVP RDITQLISHR IFTQLLRQPP NLDWLHSYQL
     VVSDSGQIQT LDGRWWNPGG SMDLKTVVSL IEPEHLELMK AQNGGLQTLL RNQHQTFQVT
     KGRVQLRWLP ERMANIVHEE VSEVEPKLKK TTAKTMDKMK TRPCWMLQNH PDGCPYPSFL
     CDFAHFEEPG Q
//

DBGET integrated database retrieval system