ID H2KUF1_CLOSI Unreviewed; 173 AA.
AC H2KUF1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 28-JUN-2023, entry version 42.
DE SubName: Full=Lysosomal aspartic protease {ECO:0000313|EMBL:GAA39721.2};
GN ORFNames=CLF_108757 {ECO:0000313|EMBL:GAA39721.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA39721.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA39721.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA39721.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; DF144068; GAA39721.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KUF1; -.
DR MEROPS; A01.057; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000313|EMBL:GAA39721.2};
KW Protease {ECO:0000313|EMBL:GAA39721.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 1..165
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT DISULFID 93..126
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 173 AA; 19867 MW; 0BF0D66932E8CF8C CRC64;
MRPEESRGKL YFGDLCVGCY YDPITYFKAE PTVGWHIKIT RIIVGDEVIF QGENRVLVDS
GTSFTFGPKT EVVAINKHLG QEEAHNGVYI IDCRRILTFP SDKFSGGIST LTLSPREYIF
RRGQLCFSSF AYRVGIKESF WRFGSALNRM FYTIYDKEED RVGFALSKIQ QDP
//