ID H2KUL0_CLOSI Unreviewed; 500 AA.
AC H2KUL0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 28-JUN-2023, entry version 30.
DE SubName: Full=Prenylcysteine oxidase {ECO:0000313|EMBL:GAA34351.2};
GN ORFNames=CLF_109431 {ECO:0000313|EMBL:GAA34351.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA34351.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA34351.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA34351.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the prenylcysteine oxidase family.
CC {ECO:0000256|ARBA:ARBA00009967}.
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DR EMBL; DF144120; GAA34351.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KUL0; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0001735; F:prenylcysteine oxidase activity; IEA:InterPro.
DR GO; GO:0030328; P:prenylcysteine catabolic process; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR010795; Prenylcys_lyase.
DR InterPro; IPR017046; Prenylcysteine_Oxase.
DR PANTHER; PTHR15944; FARNESYLCYSTEINE LYASE; 1.
DR PANTHER; PTHR15944:SF0; PRENYLCYS_LYASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR Pfam; PF07156; Prenylcys_lyase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 118..480
FT /note="Prenylcysteine lyase"
FT /evidence="ECO:0000259|Pfam:PF07156"
FT REGION 479..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 500 AA; 56245 MW; BA3F78F42CCF55AD CRC64;
MSGNPNASNF RVAIVGGGMG GSTAAYYLRQ LFGSRVAITL FEQSGRIGGR MKSIDFAGQR
EEMGASIFHE SNQYMLKFAK QFGLDIKDES KSDDRIMFYA GHEHLSFSTL GGASFLVPFR
LLWRYGIPLM QVRWYTGSII RDFVKIYSLQ DRGYCFTTTA RLFEALKPEF LEMTKWTYGD
WLSKKHRVGE TLKEEIAYGL VSNNYCQNLN VHAFVGFITM ATLLSKLFSV KGGNEQVPQR
LVDSAMKGGC PDNPSQLVNA QVTSIRSTKV ESCSWEVEYR PNDGKQIKRD TFDYVILAVP
LNQQTNIQTD GSVQLPYSEY QQVDKCLFYG SLKNWKFGIG PSSYLARQGV VICPNQTSYL
TGTCAFRSLI SFSMEKNRTN EQRIWNSFSV PRQTPDPIKS IGNEYIDQSG EKPTPPAIVN
WLAYPVYEPV QNPHEDLGKF VLAPKFYYVN AIEKMASCIE IAAIGGRNAA LLVAADMEAS
ETRNGNKNRK PLAMLDQKVR
//
