ID   H2KVB0_CLOSI            Unreviewed;       707 AA.
AC   H2KVB0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=One cut domain family member {ECO:0000256|RuleBase:RU361129};
GN   ORFNames=CLF_111721 {ECO:0000313|EMBL:GAA32120.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA32120.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA32120.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA32120.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC       ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the CUT homeobox family.
CC       {ECO:0000256|ARBA:ARBA00008190, ECO:0000256|RuleBase:RU361129}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DF144420; GAA32120.1; -; Genomic_DNA.
DR   AlphaFoldDB; H2KVB0; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   InterPro; IPR003350; CUT_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   PANTHER; PTHR14057:SF32; HOMEOBOX PROTEIN ONECUT; 1.
DR   PANTHER; PTHR14057; TRANSCRIPTION FACTOR ONECUT; 1.
DR   Pfam; PF02376; CUT; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM01109; CUT; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   PROSITE; PS51042; CUT; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   Transcription {ECO:0000256|RuleBase:RU361129};
KW   Transcription regulation {ECO:0000256|RuleBase:RU361129}.
FT   DOMAIN          259..345
FT                   /note="CUT"
FT                   /evidence="ECO:0000259|PROSITE:PS51042"
FT   DOMAIN          360..420
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        362..421
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          223..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          425..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   707 AA;  75879 MW;  93C9B14B8B2D3FCC CRC64;
     MMSSDPSNSL SASSGCGTVA MAAVPISALA PSKINFPLGD LENIPIFNSG DGAALELQAL
     QGNAQALQGI QTVKLTLINC GDQQTILLTT PSTHFTMPDQ NLDGVTLTLP DNLLATDFNL
     TGLQSFQLGD LPVMSDKCGV PDNAKLTYSN MTSLPPISSV SDKLYNQLTE DSDSVQPSHG
     YAIEDLKPVL QRNGEKLHDD NGNYSLSDPT SVALTSPVAS LPQTTFAQNI PPKPGKLMDS
     VDESSLPRQD NTDADANDPS CPDDMTELNT KDLAQRISAE LKRYTIPQAV FAQRVLCRSQ
     GTLSDLLRNP KPWSKLKSGR ETFRRMWNWL NEPEFQRMSA LRLATCKRKT EENQKPIEER
     STKKPRLVFT DIQRRTLHAI FKETKRPSKE MQATIAQQLN LEVSTVANFF MNARRRSLDK
     WVDDKDVQHT VSTSSPATSI ETSPPNHTTH VSSHLGDHCS LQPVHAALPT SQMSEVSDSV
     LHRIPGCHAG VPTSLELPSS PAPPRLTPDP TVSFSHADVD LNTLCAVSEN EHTSLSNGLL
     LSGDSAALQT QLLGHVLVGG QNAMLLSHNL SPTSDKALAQ PMSAPGLTCM ASNLSSIKSA
     LDSLSDPPTL SPAHPHHLTR VSMDSLRDTH SLQHNMTVGS VPDAVCTANH VLPSAATLIG
     HDRLGLDSVG HMSGSTVLTS SLGSSVPIHP KQEDLGSGLL GGTNALN
//